Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases

MicroRNAs (miRNAs and miRs) are a large class of noncoding, single-stranded, small RNA molecules. The precise control of their expression is essential for keeping tissue homeostasis and normal development of organisms. Thus, unbalanced expression of miRNAs is a hallmark of many diseases. Two to doze...

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Detalles Bibliográficos
Autores principales: Gu, Huanyu, Liu, Zhuyuan, Zhou, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259667/
https://www.ncbi.nlm.nih.gov/pubmed/28164128
http://dx.doi.org/10.1155/2017/9102909
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author Gu, Huanyu
Liu, Zhuyuan
Zhou, Lei
author_facet Gu, Huanyu
Liu, Zhuyuan
Zhou, Lei
author_sort Gu, Huanyu
collection PubMed
description MicroRNAs (miRNAs and miRs) are a large class of noncoding, single-stranded, small RNA molecules. The precise control of their expression is essential for keeping tissue homeostasis and normal development of organisms. Thus, unbalanced expression of miRNAs is a hallmark of many diseases. Two to dozens of miRNAs can form into a miRNA cluster, and the miR-17-92 cluster is one of them. Although firstly described as an oncogenic miRNA cluster, the miR-17-92 cluster has also been found to play critical role in normal cardiac development and cardiovascular disease. This review focuses on the characteristics and functions of miR-17-92 cluster in heart.
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spelling pubmed-52596672017-02-05 Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases Gu, Huanyu Liu, Zhuyuan Zhou, Lei Biomed Res Int Review Article MicroRNAs (miRNAs and miRs) are a large class of noncoding, single-stranded, small RNA molecules. The precise control of their expression is essential for keeping tissue homeostasis and normal development of organisms. Thus, unbalanced expression of miRNAs is a hallmark of many diseases. Two to dozens of miRNAs can form into a miRNA cluster, and the miR-17-92 cluster is one of them. Although firstly described as an oncogenic miRNA cluster, the miR-17-92 cluster has also been found to play critical role in normal cardiac development and cardiovascular disease. This review focuses on the characteristics and functions of miR-17-92 cluster in heart. Hindawi Publishing Corporation 2017 2017-01-10 /pmc/articles/PMC5259667/ /pubmed/28164128 http://dx.doi.org/10.1155/2017/9102909 Text en Copyright © 2017 Huanyu Gu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gu, Huanyu
Liu, Zhuyuan
Zhou, Lei
Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases
title Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases
title_full Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases
title_fullStr Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases
title_full_unstemmed Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases
title_short Roles of miR-17-92 Cluster in Cardiovascular Development and Common Diseases
title_sort roles of mir-17-92 cluster in cardiovascular development and common diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259667/
https://www.ncbi.nlm.nih.gov/pubmed/28164128
http://dx.doi.org/10.1155/2017/9102909
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