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Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer

Objectives. Tumour heterogeneity represents a key issue in CT perfusion (CTp), where all studies are usually based on global mean or median values of perfusion maps, often computed on whole tumour. We sought to determine whether, and to what extent, such global values can be representative of tumour...

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Autores principales: Malavasi, Silvia, Barone, Domenico, Gavelli, Giampaolo, Bevilacqua, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259676/
https://www.ncbi.nlm.nih.gov/pubmed/28164118
http://dx.doi.org/10.1155/2017/3236893
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author Malavasi, Silvia
Barone, Domenico
Gavelli, Giampaolo
Bevilacqua, Alessandro
author_facet Malavasi, Silvia
Barone, Domenico
Gavelli, Giampaolo
Bevilacqua, Alessandro
author_sort Malavasi, Silvia
collection PubMed
description Objectives. Tumour heterogeneity represents a key issue in CT perfusion (CTp), where all studies are usually based on global mean or median values of perfusion maps, often computed on whole tumour. We sought to determine whether, and to what extent, such global values can be representative of tumour heterogeneity, with respect to single slices, and could be used for therapy assessment. Materials and Methods. Twelve patients with one primary non-small cell lung cancer lesion were enrolled in this study, for a total amount of 26 CTp examinations and 118 slices. Mean and median blood flow (BF) values, calculated voxel-based, were computed on each slice and the whole tumour. To measure functional heterogeneity, entropy was calculated on BF values as well. Results. Most of the slices were not represented by the global BF values computed on the whole tumour. In addition, there are a number of lesions having equivalent global BF values, but they are composed of slices having very different heterogeneity distributions, that is, entropy values. Conclusions. Global mean/median BF values of the single slices separately should be considered for clinical assessment, only if interpreted through entropy computed on BF values. The numerical equivalence between global BF values of different lesions may correspond to different clinical status, thus inducing possible errors in choice of therapy when considering global values only.
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spelling pubmed-52596762017-02-05 Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer Malavasi, Silvia Barone, Domenico Gavelli, Giampaolo Bevilacqua, Alessandro Biomed Res Int Research Article Objectives. Tumour heterogeneity represents a key issue in CT perfusion (CTp), where all studies are usually based on global mean or median values of perfusion maps, often computed on whole tumour. We sought to determine whether, and to what extent, such global values can be representative of tumour heterogeneity, with respect to single slices, and could be used for therapy assessment. Materials and Methods. Twelve patients with one primary non-small cell lung cancer lesion were enrolled in this study, for a total amount of 26 CTp examinations and 118 slices. Mean and median blood flow (BF) values, calculated voxel-based, were computed on each slice and the whole tumour. To measure functional heterogeneity, entropy was calculated on BF values as well. Results. Most of the slices were not represented by the global BF values computed on the whole tumour. In addition, there are a number of lesions having equivalent global BF values, but they are composed of slices having very different heterogeneity distributions, that is, entropy values. Conclusions. Global mean/median BF values of the single slices separately should be considered for clinical assessment, only if interpreted through entropy computed on BF values. The numerical equivalence between global BF values of different lesions may correspond to different clinical status, thus inducing possible errors in choice of therapy when considering global values only. Hindawi Publishing Corporation 2017 2017-01-10 /pmc/articles/PMC5259676/ /pubmed/28164118 http://dx.doi.org/10.1155/2017/3236893 Text en Copyright © 2017 Silvia Malavasi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Malavasi, Silvia
Barone, Domenico
Gavelli, Giampaolo
Bevilacqua, Alessandro
Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer
title Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer
title_full Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer
title_fullStr Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer
title_full_unstemmed Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer
title_short Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer
title_sort multislice analysis of blood flow values in ct perfusion studies of lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259676/
https://www.ncbi.nlm.nih.gov/pubmed/28164118
http://dx.doi.org/10.1155/2017/3236893
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