The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells

Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xan...

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Detalles Bibliográficos
Autores principales: Sansone, Clementina, Galasso, Christian, Orefice, Ida, Nuzzo, Genoveffa, Luongo, Elvira, Cutignano, Adele, Romano, Giovanna, Brunet, Christophe, Fontana, Angelo, Esposito, Francesco, Ianora, Adrianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259714/
https://www.ncbi.nlm.nih.gov/pubmed/28117410
http://dx.doi.org/10.1038/srep41215
Descripción
Sumario:Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E(2) (PGE(2)) levels in cells damaged by H(2)O(2) and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm(TM)) indicating a potential cosmeceutical activity of this microalgal species.

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