The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells

Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xan...

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Autores principales: Sansone, Clementina, Galasso, Christian, Orefice, Ida, Nuzzo, Genoveffa, Luongo, Elvira, Cutignano, Adele, Romano, Giovanna, Brunet, Christophe, Fontana, Angelo, Esposito, Francesco, Ianora, Adrianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259714/
https://www.ncbi.nlm.nih.gov/pubmed/28117410
http://dx.doi.org/10.1038/srep41215
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author Sansone, Clementina
Galasso, Christian
Orefice, Ida
Nuzzo, Genoveffa
Luongo, Elvira
Cutignano, Adele
Romano, Giovanna
Brunet, Christophe
Fontana, Angelo
Esposito, Francesco
Ianora, Adrianna
author_facet Sansone, Clementina
Galasso, Christian
Orefice, Ida
Nuzzo, Genoveffa
Luongo, Elvira
Cutignano, Adele
Romano, Giovanna
Brunet, Christophe
Fontana, Angelo
Esposito, Francesco
Ianora, Adrianna
author_sort Sansone, Clementina
collection PubMed
description Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E(2) (PGE(2)) levels in cells damaged by H(2)O(2) and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm(TM)) indicating a potential cosmeceutical activity of this microalgal species.
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spelling pubmed-52597142017-01-24 The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells Sansone, Clementina Galasso, Christian Orefice, Ida Nuzzo, Genoveffa Luongo, Elvira Cutignano, Adele Romano, Giovanna Brunet, Christophe Fontana, Angelo Esposito, Francesco Ianora, Adrianna Sci Rep Article Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E(2) (PGE(2)) levels in cells damaged by H(2)O(2) and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm(TM)) indicating a potential cosmeceutical activity of this microalgal species. Nature Publishing Group 2017-01-24 /pmc/articles/PMC5259714/ /pubmed/28117410 http://dx.doi.org/10.1038/srep41215 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Sansone, Clementina
Galasso, Christian
Orefice, Ida
Nuzzo, Genoveffa
Luongo, Elvira
Cutignano, Adele
Romano, Giovanna
Brunet, Christophe
Fontana, Angelo
Esposito, Francesco
Ianora, Adrianna
The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells
title The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells
title_full The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells
title_fullStr The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells
title_full_unstemmed The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells
title_short The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells
title_sort green microalga tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259714/
https://www.ncbi.nlm.nih.gov/pubmed/28117410
http://dx.doi.org/10.1038/srep41215
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