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Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway

Our previous studies demonstrated that volatile oil from saussurea lappa root (VOSL), rich in two natural sesquiterpene lactones, costunolide (Cos) and dehydrocostuslactone (Dehy), exerts better anti-breast cancer efficacy and lower side effects than Cos or Dehy alone in vivo, however, their anti-ca...

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Detalles Bibliográficos
Autores principales:	Peng, Zhangxiao, Wang, Yan, Fan, Jianhui, Lin, Xuejing, Liu, Chunying, Xu, Yang, Ji, Weidan, Yan, Chao, Su, Changqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259746/ https://www.ncbi.nlm.nih.gov/pubmed/28117370 http://dx.doi.org/10.1038/srep41254

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