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Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis

The catabolism of tryptophan to immunosuppressive and neuroactive kynurenines is a key metabolic pathway regulating immune responses and neurotoxicity. The rate-limiting step is controlled by indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO). IDO is expressed in antigen presenti...

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Detalles Bibliográficos
Autores principales:	Lanz, Tobias V., Williams, Sarah K., Stojic, Aleksandar, Iwantscheff, Simeon, Sonner, Jana K., Grabitz, Carl, Becker, Simon, Böhler, Laura-Inés, Mohapatra, Soumya R., Sahm, Felix, Küblbeck, Günter, Nakamura, Toshikazu, Funakoshi, Hiroshi, Opitz, Christiane A., Wick, Wolfgang, Diem, Ricarda, Platten, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259766/ https://www.ncbi.nlm.nih.gov/pubmed/28117398 http://dx.doi.org/10.1038/srep41271

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