A new serotonin 5-HT(6) receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding

Serotonin 5-HT(6) receptor has been proposed as a promising therapeutic target for cognition enhancement though the development of new antagonists is still needed to validate these molecules as a drug class for the treatment of Alzheimer’s disease and other pathologies associated with memory deficie...

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Detalles Bibliográficos
Autores principales: González-Vera, Juan A., Medina, Rocío A., Martín-Fontecha, Mar, Gonzalez, Angel, de la Fuente, Tania, Vázquez-Villa, Henar, García-Cárceles, Javier, Botta, Joaquín, McCormick, Peter J., Benhamú, Bellinda, Pardo, Leonardo, López-Rodríguez, María L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259792/
https://www.ncbi.nlm.nih.gov/pubmed/28117458
http://dx.doi.org/10.1038/srep41293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259792/
https://www.ncbi.nlm.nih.gov/pubmed/28117458
http://dx.doi.org/10.1038/srep41293

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