Integrated analysis of hematopoietic differentiation outcomes and molecular characterization reveals unbiased differentiation capacity and minor transcriptional memory in HPC/HSC-iPSCs

BACKGROUND: Transcription factor-mediated reprogramming can reset the epigenetics of somatic cells into a pluripotency compatible state. Recent studies show that induced pluripotent stem cells (iPSCs) always inherit starting cell-specific characteristics, called epigenetic memory, which may be advan...

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Detalles Bibliográficos
Autores principales: Gao, Shuai, Hou, Xinfeng, Jiang, Yonghua, Xu, Zijian, Cai, Tao, Chen, Jiajie, Chang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259886/
https://www.ncbi.nlm.nih.gov/pubmed/28114969
http://dx.doi.org/10.1186/s13287-016-0466-1

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