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Hemodynamics study of a multilayer stent for the treatment of aneurysms

BACKGROUND: The changes of hemodynamics caused by the implantation of multilayer stent (MS) have significant effects for aneurysm sac. METHODS: Comparisons of 3D numerical models with/without a MS in an abdominal aortic aneurysm with a 90° branch vessel were numerically studied from the viewpoint of...

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Autores principales: Xiong, Yan, Wang, Xuhong, Jiang, Wentao, Tian, Xiaobao, Wang, Qingyuan, Fan, Yubo, Chen, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260060/
https://www.ncbi.nlm.nih.gov/pubmed/28155682
http://dx.doi.org/10.1186/s12938-016-0248-0
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author Xiong, Yan
Wang, Xuhong
Jiang, Wentao
Tian, Xiaobao
Wang, Qingyuan
Fan, Yubo
Chen, Yu
author_facet Xiong, Yan
Wang, Xuhong
Jiang, Wentao
Tian, Xiaobao
Wang, Qingyuan
Fan, Yubo
Chen, Yu
author_sort Xiong, Yan
collection PubMed
description BACKGROUND: The changes of hemodynamics caused by the implantation of multilayer stent (MS) have significant effects for aneurysm sac. METHODS: Comparisons of 3D numerical models with/without a MS in an abdominal aortic aneurysm with a 90° branch vessel were numerically studied from the viewpoint of hemodynamics. RESULTS: The results showed that: (1) The flow fields and Wall Shear Stress (WSS) are changed dramatically after MS implantation. The velocity of the blood flow in aneurysm sac decreases significantly and the regions of low-WSS increase. These help thrombus formation; (2) The pressure in aneurysm slightly decreases and keeps close to the normal level of blood pressure, however the risk of aneurysm enlargement or even rupture still exists; (3) The flux and the velocity in branch artery are reduced by about half after MS implantation. Due to the implantation of MS, the changes in the flow field causes the decrease of pressure/WSS in aneurysm sac and the blood flow in branch vessel. CONCLUSIONS: The implantation of MS into abdominal artery results in more low-WSS regions inside aneurysm which induces thrombus formation. The pressure is reduced slightly means the risk of aneurysm rupture exists.
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spelling pubmed-52600602017-01-26 Hemodynamics study of a multilayer stent for the treatment of aneurysms Xiong, Yan Wang, Xuhong Jiang, Wentao Tian, Xiaobao Wang, Qingyuan Fan, Yubo Chen, Yu Biomed Eng Online Research BACKGROUND: The changes of hemodynamics caused by the implantation of multilayer stent (MS) have significant effects for aneurysm sac. METHODS: Comparisons of 3D numerical models with/without a MS in an abdominal aortic aneurysm with a 90° branch vessel were numerically studied from the viewpoint of hemodynamics. RESULTS: The results showed that: (1) The flow fields and Wall Shear Stress (WSS) are changed dramatically after MS implantation. The velocity of the blood flow in aneurysm sac decreases significantly and the regions of low-WSS increase. These help thrombus formation; (2) The pressure in aneurysm slightly decreases and keeps close to the normal level of blood pressure, however the risk of aneurysm enlargement or even rupture still exists; (3) The flux and the velocity in branch artery are reduced by about half after MS implantation. Due to the implantation of MS, the changes in the flow field causes the decrease of pressure/WSS in aneurysm sac and the blood flow in branch vessel. CONCLUSIONS: The implantation of MS into abdominal artery results in more low-WSS regions inside aneurysm which induces thrombus formation. The pressure is reduced slightly means the risk of aneurysm rupture exists. BioMed Central 2016-12-28 /pmc/articles/PMC5260060/ /pubmed/28155682 http://dx.doi.org/10.1186/s12938-016-0248-0 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Xiong, Yan
Wang, Xuhong
Jiang, Wentao
Tian, Xiaobao
Wang, Qingyuan
Fan, Yubo
Chen, Yu
Hemodynamics study of a multilayer stent for the treatment of aneurysms
title Hemodynamics study of a multilayer stent for the treatment of aneurysms
title_full Hemodynamics study of a multilayer stent for the treatment of aneurysms
title_fullStr Hemodynamics study of a multilayer stent for the treatment of aneurysms
title_full_unstemmed Hemodynamics study of a multilayer stent for the treatment of aneurysms
title_short Hemodynamics study of a multilayer stent for the treatment of aneurysms
title_sort hemodynamics study of a multilayer stent for the treatment of aneurysms
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260060/
https://www.ncbi.nlm.nih.gov/pubmed/28155682
http://dx.doi.org/10.1186/s12938-016-0248-0
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