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Local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis
BACKGROUND: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) were to evaluate the effect and safety of local anesthetic infusion pump versus placebo for pain management following total knee arthroplasty (TKA). METHODS: In September 2016, a systematic computer...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260107/ https://www.ncbi.nlm.nih.gov/pubmed/28114927 http://dx.doi.org/10.1186/s12891-016-1382-3 |
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author | Zhang, Yeying Lu, Ming Chang, Cheng |
author_facet | Zhang, Yeying Lu, Ming Chang, Cheng |
author_sort | Zhang, Yeying |
collection | PubMed |
description | BACKGROUND: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) were to evaluate the effect and safety of local anesthetic infusion pump versus placebo for pain management following total knee arthroplasty (TKA). METHODS: In September 2016, a systematic computer-based search was conducted in the Pubmed, ISI Web of Knowledge, Embase, Cochrane Database of Systematic Reviews. Randomized controlled trials of patients prepared for primary TKA that compared local anesthetic infusion pump versus placebo for pain management following TKA were retrieved. The primary endpoint was the visual analogue scale (VAS) with rest or mobilization at 24, 48 and 72 h and morphine consumption at 24 and 48 h. The second outcomes are range of motion, length of hospital stay (LOS) and complications (infection, deep venous thrombosis (DVT), prolonged drainage and postoperative nausea and vomiting (PONV)). RESULTS: Seven clinical studies with 587 patients were included and for meta-analysis. Local anesthetic infusion pump are associated with less pain scores with rest or mobilization at 24 and 48 h with significant difference. However, the difference was likely no clinical significance. There were no significant difference between the LOS, the occurrence of DVT, prolonged drainage and PONV. However, local anesthetic infusion pump may be associated with more infection. CONCLUSION: Based on the current meta-analysis, we found no evidence to support the routine use of local anesthetic infusion pump in the management of acute pain following TKA. More RCTs are still need to identify the pain control effects and optimal dose and speed of local anesthetic pain pump. |
format | Online Article Text |
id | pubmed-5260107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52601072017-01-26 Local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis Zhang, Yeying Lu, Ming Chang, Cheng BMC Musculoskelet Disord Research Article BACKGROUND: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) were to evaluate the effect and safety of local anesthetic infusion pump versus placebo for pain management following total knee arthroplasty (TKA). METHODS: In September 2016, a systematic computer-based search was conducted in the Pubmed, ISI Web of Knowledge, Embase, Cochrane Database of Systematic Reviews. Randomized controlled trials of patients prepared for primary TKA that compared local anesthetic infusion pump versus placebo for pain management following TKA were retrieved. The primary endpoint was the visual analogue scale (VAS) with rest or mobilization at 24, 48 and 72 h and morphine consumption at 24 and 48 h. The second outcomes are range of motion, length of hospital stay (LOS) and complications (infection, deep venous thrombosis (DVT), prolonged drainage and postoperative nausea and vomiting (PONV)). RESULTS: Seven clinical studies with 587 patients were included and for meta-analysis. Local anesthetic infusion pump are associated with less pain scores with rest or mobilization at 24 and 48 h with significant difference. However, the difference was likely no clinical significance. There were no significant difference between the LOS, the occurrence of DVT, prolonged drainage and PONV. However, local anesthetic infusion pump may be associated with more infection. CONCLUSION: Based on the current meta-analysis, we found no evidence to support the routine use of local anesthetic infusion pump in the management of acute pain following TKA. More RCTs are still need to identify the pain control effects and optimal dose and speed of local anesthetic pain pump. BioMed Central 2017-01-23 /pmc/articles/PMC5260107/ /pubmed/28114927 http://dx.doi.org/10.1186/s12891-016-1382-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Zhang, Yeying Lu, Ming Chang, Cheng Local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis |
title | Local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis |
title_full | Local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis |
title_fullStr | Local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis |
title_full_unstemmed | Local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis |
title_short | Local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis |
title_sort | local anesthetic infusion pump for pain management following total knee arthroplasty: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260107/ https://www.ncbi.nlm.nih.gov/pubmed/28114927 http://dx.doi.org/10.1186/s12891-016-1382-3 |
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