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Rapidly cycling Lgr5(+) stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk

The majority of colon tumors are driven by aberrant Wnt signaling in intestinal stem cells, which mediates an efficient route toward initiating intestinal cancer. Natural lipophilic polyphenols and long-chain polyunsaturated fatty acids (PUFAs) generally suppress Wnt- and NF-κB- (nuclear factor-κ li...

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Detalles Bibliográficos
Autores principales:	Kim, Eunjoo, Davidson, Laurie A, Zoh, Roger S, Hensel, Martha E, Salinas, Michael L, Patil, Bhimanagouda S, Jayaprakasha, Guddadarangavvanahally K, Callaway, Evelyn S, Allred, Clinton D, Turner, Nancy D, Weeks, Brad R, Chapkin, Robert S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260883/ https://www.ncbi.nlm.nih.gov/pubmed/27831561 http://dx.doi.org/10.1038/cddis.2016.269

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