Multiple functions of USP18

Since the discovery of the ubiquitin system and the description of its important role in the degradation of proteins, many studies have shown the importance of ubiquitin-specific peptidases (USPs). One special member of this family is the USP18 protein (formerly UBP43). In the past two decades, seve...

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Detalles Bibliográficos
Autores principales: Honke, Nadine, Shaabani, Namir, Zhang, Dong-Er, Hardt, Cornelia, Lang, Karl S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260889/
https://www.ncbi.nlm.nih.gov/pubmed/27809302
http://dx.doi.org/10.1038/cddis.2016.326
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author Honke, Nadine
Shaabani, Namir
Zhang, Dong-Er
Hardt, Cornelia
Lang, Karl S
author_facet Honke, Nadine
Shaabani, Namir
Zhang, Dong-Er
Hardt, Cornelia
Lang, Karl S
author_sort Honke, Nadine
collection PubMed
description Since the discovery of the ubiquitin system and the description of its important role in the degradation of proteins, many studies have shown the importance of ubiquitin-specific peptidases (USPs). One special member of this family is the USP18 protein (formerly UBP43). In the past two decades, several functions of USP18 have been discovered: this protein is not only an isopeptidase but also a potent inhibitor of interferon signaling. Therefore, USP18 functions as 'a' maestro of many biological pathways in various cell types. This review outlines multiple functions of USP18 in the regulation of various immunological processes, including pathogen control, cancer development, and autoimmune diseases.
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spelling pubmed-52608892017-01-26 Multiple functions of USP18 Honke, Nadine Shaabani, Namir Zhang, Dong-Er Hardt, Cornelia Lang, Karl S Cell Death Dis Review Since the discovery of the ubiquitin system and the description of its important role in the degradation of proteins, many studies have shown the importance of ubiquitin-specific peptidases (USPs). One special member of this family is the USP18 protein (formerly UBP43). In the past two decades, several functions of USP18 have been discovered: this protein is not only an isopeptidase but also a potent inhibitor of interferon signaling. Therefore, USP18 functions as 'a' maestro of many biological pathways in various cell types. This review outlines multiple functions of USP18 in the regulation of various immunological processes, including pathogen control, cancer development, and autoimmune diseases. Nature Publishing Group 2016-11 2016-11-03 /pmc/articles/PMC5260889/ /pubmed/27809302 http://dx.doi.org/10.1038/cddis.2016.326 Text en Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature.
spellingShingle Review
Honke, Nadine
Shaabani, Namir
Zhang, Dong-Er
Hardt, Cornelia
Lang, Karl S
Multiple functions of USP18
title Multiple functions of USP18
title_full Multiple functions of USP18
title_fullStr Multiple functions of USP18
title_full_unstemmed Multiple functions of USP18
title_short Multiple functions of USP18
title_sort multiple functions of usp18
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260889/
https://www.ncbi.nlm.nih.gov/pubmed/27809302
http://dx.doi.org/10.1038/cddis.2016.326
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