GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal

G protein-coupled receptor kinases (GRKs) are critically involved in immune response through regulation of cytokine receptors in mature leukocytes, but their role in hematopoiesis is largely unknown. Here, we demonstrate that GRK6 knockout (GRK6(−/−)) mice exhibit lymphocytopenia, loss of the hemato...

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Detalles Bibliográficos
Autores principales: Le, Qiumin, Yao, Wenqing, Chen, Yuejun, Yan, Biao, Liu, Cao, Yuan, Man, Zhou, Yuqing, Ma, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260904/
https://www.ncbi.nlm.nih.gov/pubmed/27882944
http://dx.doi.org/10.1038/cddis.2016.377

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