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Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation
Hyperhomocysteinemia (HHcy) is a well-known risk factor for stroke; however, its underlying molecular mechanism remains unclear. Using both mouse and cell culture models, we have provided evidence that impairment of autophagy has a central role in HHcy-induced cellular injury in the mouse brain. We...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260994/ https://www.ncbi.nlm.nih.gov/pubmed/27929536 http://dx.doi.org/10.1038/cddis.2016.374 |