Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancer

Epigenetic silencing of tumor suppressors contributes to the development and progression of colorectal cancer (CRC). We recently found that speckle-type POZ protein (SPOP) was significantly downregulated and the inactivation of SPOP promoted metastasis in CRC. This study aimed to clarify its epigene...

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Detalles Bibliográficos
Autores principales: Zhi, Xiaofei, Tao, Jinqiu, Zhang, Lei, Tao, Ran, Ma, Lilin, Qin, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261007/
https://www.ncbi.nlm.nih.gov/pubmed/28032859
http://dx.doi.org/10.1038/cddis.2016.435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261007/
https://www.ncbi.nlm.nih.gov/pubmed/28032859
http://dx.doi.org/10.1038/cddis.2016.435

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