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Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to oxygen-limiting conditions. This adaptation includes suppression of mitochondrial activity, induction of anerobic glycolysis, and activation of hypoxia-inducible transcription factor 1α...

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Detalles Bibliográficos
Autores principales:	Bejarano-García, José Antonio, Millán-Uclés, África, Rosado, Iván V, Sánchez-Abarca, Luís Ignacio, Caballero-Velázquez, Teresa, Durán-Galván, María José, Pérez-Simón, José Antonio, Piruat, José I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261010/ https://www.ncbi.nlm.nih.gov/pubmed/27929539 http://dx.doi.org/10.1038/cddis.2016.411

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