E2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion

Cerebral ischemia/reperfusion (I/R) causes brain damage accompanied by ubiquitin accumulation and impairment of proteasome activity. In this study, we report that E2-25K, an E2-conjugating enzyme, is SUMOylated during oxidative stress and regulates cerebral I/R-induced damage. Knockdown of E2-25K ex...

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Detalles Bibliográficos
Autores principales: Jeong, Eun Il, Chung, Hae Won, Lee, Won Jea, Kim, Seo-Hyun, Kim, Hyunjoo, Choi, Seon-Guk, Jung, Yong-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261013/
https://www.ncbi.nlm.nih.gov/pubmed/28032866
http://dx.doi.org/10.1038/cddis.2016.428

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