Distinct outcomes of CRL–Nedd8 pathway inhibition reveal cancer cell plasticity

Inhibition of protein degradation by blocking Cullin-RING E3 ligases (CRLs) is a new approach in cancer therapy though of unknown risk because CRL inhibition may stabilize both oncoproteins and tumor suppressors. Probing CRLs in prostate cancer cells revealed a remarkable plasticity of cells with TM...

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Detalles Bibliográficos
Autores principales: Rulina, Anastasia V, Mittler, Frédérique, Obeid, Patricia, Gerbaud, Sophie, Guyon, Laurent, Sulpice, Eric, Kermarrec, Frédérique, Assard, Nicole, Dolega, Monika E, Gidrol, Xavier, Balakirev, Maxim Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261022/
https://www.ncbi.nlm.nih.gov/pubmed/27906189
http://dx.doi.org/10.1038/cddis.2016.395

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