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Autonomic Modulation in Duchenne Muscular Dystrophy during a Computer Task: A Prospective Control Trial

INTRODUCTION: Duchenne Muscular Dystrophy (DMD) is characterized by progressive muscle weakness that can lead to disability. Owing to functional difficulties faced by individuals with DMD, the use of assistive technology is essential to provide or facilitate functional abilities. In DMD, cardiac aut...

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Autores principales: Alvarez, Mayra Priscila Boscolo, da Silva, Talita Dias, Favero, Francis Meire, Valenti, Vitor Engrácia, Raimundo, Rodrigo Daminello, Vanderlei, Luiz Carlos Marques, Garner, David M., Monteiro, Carlos Bandeira de Mello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261738/
https://www.ncbi.nlm.nih.gov/pubmed/28118369
http://dx.doi.org/10.1371/journal.pone.0169633
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author Alvarez, Mayra Priscila Boscolo
da Silva, Talita Dias
Favero, Francis Meire
Valenti, Vitor Engrácia
Raimundo, Rodrigo Daminello
Vanderlei, Luiz Carlos Marques
Garner, David M.
Monteiro, Carlos Bandeira de Mello
author_facet Alvarez, Mayra Priscila Boscolo
da Silva, Talita Dias
Favero, Francis Meire
Valenti, Vitor Engrácia
Raimundo, Rodrigo Daminello
Vanderlei, Luiz Carlos Marques
Garner, David M.
Monteiro, Carlos Bandeira de Mello
author_sort Alvarez, Mayra Priscila Boscolo
collection PubMed
description INTRODUCTION: Duchenne Muscular Dystrophy (DMD) is characterized by progressive muscle weakness that can lead to disability. Owing to functional difficulties faced by individuals with DMD, the use of assistive technology is essential to provide or facilitate functional abilities. In DMD, cardiac autonomic dysfunction has been reported in addition to musculoskeletal impairment. Consequently, the objective was to investigate acute cardiac autonomic responses, by Heart Rate Variability (HRV), during computer tasks in subjects with DMD. METHOD: HRV was assessed by linear and nonlinear methods, using the heart rate monitor Polar RS800CX chest strap Electrocardiographic measuring device. Then, 45 subjects were included in the group with DMD and 45 in the healthy Typical Development (TD) control group. They were assessed for twenty minutes at rest sitting, and five minutes after undergoing a task on the computer. RESULTS: Individuals with DMD had a statistically significant lower parasympathetic cardiac modulation at rest when compared to the control group, which further declined when undergoing the tasks on the computer. CONCLUSION: DMD patients presented decreased HRV and exhibited greater intensity of cardiac autonomic responses during computer tasks characterized by vagal withdrawal when compared to the healthy TD control subjects.
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spelling pubmed-52617382017-02-17 Autonomic Modulation in Duchenne Muscular Dystrophy during a Computer Task: A Prospective Control Trial Alvarez, Mayra Priscila Boscolo da Silva, Talita Dias Favero, Francis Meire Valenti, Vitor Engrácia Raimundo, Rodrigo Daminello Vanderlei, Luiz Carlos Marques Garner, David M. Monteiro, Carlos Bandeira de Mello PLoS One Research Article INTRODUCTION: Duchenne Muscular Dystrophy (DMD) is characterized by progressive muscle weakness that can lead to disability. Owing to functional difficulties faced by individuals with DMD, the use of assistive technology is essential to provide or facilitate functional abilities. In DMD, cardiac autonomic dysfunction has been reported in addition to musculoskeletal impairment. Consequently, the objective was to investigate acute cardiac autonomic responses, by Heart Rate Variability (HRV), during computer tasks in subjects with DMD. METHOD: HRV was assessed by linear and nonlinear methods, using the heart rate monitor Polar RS800CX chest strap Electrocardiographic measuring device. Then, 45 subjects were included in the group with DMD and 45 in the healthy Typical Development (TD) control group. They were assessed for twenty minutes at rest sitting, and five minutes after undergoing a task on the computer. RESULTS: Individuals with DMD had a statistically significant lower parasympathetic cardiac modulation at rest when compared to the control group, which further declined when undergoing the tasks on the computer. CONCLUSION: DMD patients presented decreased HRV and exhibited greater intensity of cardiac autonomic responses during computer tasks characterized by vagal withdrawal when compared to the healthy TD control subjects. Public Library of Science 2017-01-24 /pmc/articles/PMC5261738/ /pubmed/28118369 http://dx.doi.org/10.1371/journal.pone.0169633 Text en © 2017 Alvarez et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alvarez, Mayra Priscila Boscolo
da Silva, Talita Dias
Favero, Francis Meire
Valenti, Vitor Engrácia
Raimundo, Rodrigo Daminello
Vanderlei, Luiz Carlos Marques
Garner, David M.
Monteiro, Carlos Bandeira de Mello
Autonomic Modulation in Duchenne Muscular Dystrophy during a Computer Task: A Prospective Control Trial
title Autonomic Modulation in Duchenne Muscular Dystrophy during a Computer Task: A Prospective Control Trial
title_full Autonomic Modulation in Duchenne Muscular Dystrophy during a Computer Task: A Prospective Control Trial
title_fullStr Autonomic Modulation in Duchenne Muscular Dystrophy during a Computer Task: A Prospective Control Trial
title_full_unstemmed Autonomic Modulation in Duchenne Muscular Dystrophy during a Computer Task: A Prospective Control Trial
title_short Autonomic Modulation in Duchenne Muscular Dystrophy during a Computer Task: A Prospective Control Trial
title_sort autonomic modulation in duchenne muscular dystrophy during a computer task: a prospective control trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261738/
https://www.ncbi.nlm.nih.gov/pubmed/28118369
http://dx.doi.org/10.1371/journal.pone.0169633
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