MEDICI: Mining Essentiality Data to Identify Critical Interactions for Cancer Drug Target Discovery and Development

Protein-protein interactions (PPIs) mediate the transmission and regulation of oncogenic signals that are essential to cellular proliferation and survival, and thus represent potential targets for anti-cancer therapeutic discovery. Despite their significance, there is no method to experimentally dis...

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Detalles Bibliográficos
Autores principales: Harati, Sahar, Cooper, Lee A. D., Moran, Josue D., Giuste, Felipe O., Du, Yuhong, Ivanov, Andrei A., Johns, Margaret A., Khuri, Fadlo R., Fu, Haian, Moreno, Carlos S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261804/
https://www.ncbi.nlm.nih.gov/pubmed/28118365
http://dx.doi.org/10.1371/journal.pone.0170339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261804/
https://www.ncbi.nlm.nih.gov/pubmed/28118365
http://dx.doi.org/10.1371/journal.pone.0170339

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