Cargando…

Inhibition of Skp2 sensitizes lung cancer cells to paclitaxel

S-phase kinase-associated protein 2 (Skp2) is an E3 ubiquitin ligase and plays an important role in the control of cell cycle progression. Skp2 is upregulated in several cancers, including lung cancers, but the role of Skp2 in the tumorigenesis and anticancer drug resistance in human lung cancer rem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Tonghai, Yang, Lin, Wang, Guangsuo, Ding, Guanggui, Peng, Bin, Wen, Yuxin, Wang, Zheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261849/ https://www.ncbi.nlm.nih.gov/pubmed/28176922 http://dx.doi.org/10.2147/OTT.S125789

Ejemplares similares

miR-10a increases the cisplatin resistance of lung adenocarcinoma circulating tumor cells via targeting PIK3CA in the PI3K/Akt pathway
por: Huang, Tonghai, et al.
Publicado: (2020)

Acquisition of epithelial–mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells
por: Yang, Q, et al.
Publicado: (2014)

Inhibition of SKP2 Sensitizes Bromocriptine-Induced Apoptosis in Human Prolactinoma Cells
por: Huang, Jinxiang, et al.
Publicado: (2017)

Inhibition of Skp2 Sensitizes Chronic Myeloid Leukemia Cells to Imatinib
por: Chen, Xiaowen, et al.
Publicado: (2020)

Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma
por: Zhang, Yidan, et al.
Publicado: (2018)

Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
por: Wu, Lichuan, et al.
Publicado: (2016)

Overexpression of SKP2 Inhibits the Radiation-Induced Bystander Effects of Esophageal Carcinoma
por: Wang, Xiao-Chun, et al.
Publicado: (2017)

HSP70 via HIF-1 α SUMOylation inhibits ferroptosis inducing lung cancer recurrence after insufficient radiofrequency ablation
por: Peng, Bin, et al.
Publicado: (2023)

Independent prognostic value of HIF-1α expression in radiofrequency ablation of lung cancer
por: Wan, Jun, et al.
Publicado: (2020)

miR-142-5p regulates CD4(+) T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway
por: Wan, Jun, et al.
Publicado: (2018)

MicroRNA-137 inhibits tumor growth and sensitizes chemosensitivity to paclitaxel and cisplatin in lung cancer
por: Shen, Hua, et al.
Publicado: (2016)

Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors
por: Liu, Yong-Qiang, et al.
Publicado: (2015)

Glucosamine‐phosphate N‐acetyltransferase 1 and its DNA methylation can be biomarkers for the diagnosis and prognosis of lung cancer
por: Ding, Peikun, et al.
Publicado: (2022)

Paeoniflorin inhibits cell viability and invasion of liver cancer cells via inhibition of Skp2
por: Liu, Hong, et al.
Publicado: (2020)

Potential Impact of Cancer Susceptibility Genes on Lung Cancer Metastasis
por: Wang, Jiaqing, et al.
Publicado: (2022)

Gastrodin overcomes chemoresistance via inhibiting Skp2-mediated glycolysis
por: Xie, Li, et al.
Publicado: (2023)

Effects of RNAi-induced Skp2 inhibition on cell cycle, apoptosis and proliferation of endometrial carcinoma cells
por: Lin, Hao, et al.
Publicado: (2019)

Suppression of pyruvate dehydrogenase kinase-2 re-sensitizes paclitaxel-resistant human lung cancer cells to paclitaxel
por: Sun, Hong, et al.
Publicado: (2017)

Dioscin: A new potential inhibitor of Skp2 for cancer therapy
por: Jiang, Wenxiao, et al.
Publicado: (2020)

Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade
por: Mickova, Alena, et al.
Publicado: (2021)

MicroRNA-7 sensitizes non-small cell lung cancer cells to paclitaxel
por: LIU, RONGHUA, et al.
Publicado: (2014)

Skp2 and Skp2B team up against Rb and p53
por: Germain, Doris
Publicado: (2011)

USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates
por: Zhang, Fengwu, et al.
Publicado: (2021)

Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression
por: Chan, Chia-Hsin, et al.
Publicado: (2010)

The Conserved Function of Skp1 in Meiosis
por: McLoud, Josh D., et al.
Publicado: (2012)

Long-Term Survival After Salvage Thoracic Surgery on a Patient with ALK-Rearranged Metastatic Lung Adenocarcinoma After Progression on Targeted Therapy
por: Ren, Kangqi, et al.
Publicado: (2021)

Drosophila Skp1 Homologue SkpA Plays a Neuroprotective Role in Adult Brain
por: Dabool, Lital, et al.
Publicado: (2020)

SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma
por: Salaroglio, Iris Chiara, et al.
Publicado: (2022)

Activity and mechanism of flavokawain A in inhibiting P-glycoprotein expression in paclitaxel resistance of lung cancer
por: Li, Juan, et al.
Publicado: (2020)

Rottlerin exerts its anti-tumor activity through inhibition of Skp2 in breast cancer cells
por: Yin, Xuyuan, et al.
Publicado: (2016)

MiR-506 exerts antineoplastic effects on osteosarcoma cells via inhibition of the Skp2 oncoprotein
por: Ding, Lu, et al.
Publicado: (2021)

Inhibition of Lipolysis by Mercaptoacetate and Etomoxir Specifically Sensitize Drug-Resistant Lung Adenocarcinoma Cell to Paclitaxel
por: Li, Jiajin, et al.
Publicado: (2013)

Skp2 is a Promising Therapeutic Target in Breast Cancer
por: Wang, Zhiwei, et al.
Publicado: (2012)

SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation
por: Li, Ziming, et al.
Publicado: (2016)

USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia
por: Liao, Yuning, et al.
Publicado: (2019)

Emerging Roles of SKP2 in Cancer Drug Resistance
por: Wu, Ting, et al.
Publicado: (2021)

Skp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells
por: Zhou, Huiling, et al.
Publicado: (2023)

Skp2 expression has different clinicopathological and prognostic implications in lung adenocarcinoma and squamous cell carcinoma
por: Zhong, Kaize, et al.
Publicado: (2018)

Oxygen-Carbon Nanotubes as a Chemotherapy Sensitizer for Paclitaxel in Breast Cancer Treatment
por: Wang, Yongkun, et al.
Publicado: (2014)

Skp2: A dream target in the coming age of cancer therapy
por: Chan, Chia-Hsin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jh0f5hsahsb54n16706lj1prnk