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Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes

BACKGROUND: In view of the disturbed esophageal peristaltic activity and abnormal esophageal motility in gastroesophageal reflux disease, (GERD), we investigated the hypothesis that these changes result from a disordered myoelectric activity of the esophagus. METHODS: The electric activity of the es...

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Autores principales: Shafik, Ahmed, El-Sibai, Olfat, Shafik, Ismail, Shafik, Ali
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC526194/
https://www.ncbi.nlm.nih.gov/pubmed/15462680
http://dx.doi.org/10.1186/1471-2482-4-13
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author Shafik, Ahmed
El-Sibai, Olfat
Shafik, Ismail
Shafik, Ali
author_facet Shafik, Ahmed
El-Sibai, Olfat
Shafik, Ismail
Shafik, Ali
author_sort Shafik, Ahmed
collection PubMed
description BACKGROUND: In view of the disturbed esophageal peristaltic activity and abnormal esophageal motility in gastroesophageal reflux disease, (GERD), we investigated the hypothesis that these changes result from a disordered myoelectric activity of the esophagus. METHODS: The electric activity of the esophagus (electroesophagogram, EEG) was studied in 27 patients with GERD (16 men, 11 women, mean age 42.6 ± 5.2 years) and 10 healthy volunteers as controls (6 men, 4 women, mean age 41.4 ± 4.9 years). According to the Feussner scoring system, 7 patients had a mild (score 1), 10 a moderate (score 2) and 10 a severe (score 3) stage of the disease. One electrode was applied to the upper third and a second to the lower third of the esophagus, and the electric activity was recorded. The test was repeated after the upper electrode had been moved to the mid-esophagus. RESULTS: The EEG of the healthy volunteers showed slow waves and exhibited the same frequency, amplitude and conduction velocity from the 2 electrodes of the individual subject, regardless of their location in the upper, middle or lower esophagus. Action potentials occurred randomly. In GERD patients, score 1 exhibited electric waves' variables similar to those of the healthy volunteers. In score 2, the waves recorded irregular rhythm and lower variables than the controls. Score 3 showed a "silent" EEG without waves. CONCLUSION: The electric activity in GERD exhibited 3 different patterns depending on the stages of GERD. Score 1 exhibited a normal EEG which apparently denotes normal esophageal motility. Score 2 recorded irregular electric waves variables which are presumably indicative of decreased esophageal motility and reflux clearance. In score 3, a "silent" EEG was recorded with probably no acid clearance. It is postulated that the interstitial cells of Cajal which are the electric activity generators, are involved in the inflammatory process of GERD. Destruction of these cells appears to occur in grades that are in accordance with GERD scores. The EEG seems to have the potential to act as an investigative tool in the diagnosis of GERD stages.
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spelling pubmed-5261942004-11-10 Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes Shafik, Ahmed El-Sibai, Olfat Shafik, Ismail Shafik, Ali BMC Surg Research Article BACKGROUND: In view of the disturbed esophageal peristaltic activity and abnormal esophageal motility in gastroesophageal reflux disease, (GERD), we investigated the hypothesis that these changes result from a disordered myoelectric activity of the esophagus. METHODS: The electric activity of the esophagus (electroesophagogram, EEG) was studied in 27 patients with GERD (16 men, 11 women, mean age 42.6 ± 5.2 years) and 10 healthy volunteers as controls (6 men, 4 women, mean age 41.4 ± 4.9 years). According to the Feussner scoring system, 7 patients had a mild (score 1), 10 a moderate (score 2) and 10 a severe (score 3) stage of the disease. One electrode was applied to the upper third and a second to the lower third of the esophagus, and the electric activity was recorded. The test was repeated after the upper electrode had been moved to the mid-esophagus. RESULTS: The EEG of the healthy volunteers showed slow waves and exhibited the same frequency, amplitude and conduction velocity from the 2 electrodes of the individual subject, regardless of their location in the upper, middle or lower esophagus. Action potentials occurred randomly. In GERD patients, score 1 exhibited electric waves' variables similar to those of the healthy volunteers. In score 2, the waves recorded irregular rhythm and lower variables than the controls. Score 3 showed a "silent" EEG without waves. CONCLUSION: The electric activity in GERD exhibited 3 different patterns depending on the stages of GERD. Score 1 exhibited a normal EEG which apparently denotes normal esophageal motility. Score 2 recorded irregular electric waves variables which are presumably indicative of decreased esophageal motility and reflux clearance. In score 3, a "silent" EEG was recorded with probably no acid clearance. It is postulated that the interstitial cells of Cajal which are the electric activity generators, are involved in the inflammatory process of GERD. Destruction of these cells appears to occur in grades that are in accordance with GERD scores. The EEG seems to have the potential to act as an investigative tool in the diagnosis of GERD stages. BioMed Central 2004-10-05 /pmc/articles/PMC526194/ /pubmed/15462680 http://dx.doi.org/10.1186/1471-2482-4-13 Text en Copyright © 2004 Shafik et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shafik, Ahmed
El-Sibai, Olfat
Shafik, Ismail
Shafik, Ali
Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes
title Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes
title_full Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes
title_fullStr Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes
title_full_unstemmed Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes
title_short Electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes
title_sort electroesophagogram in gastroesophageal reflux disease with a new theory on the pathogenesis of its electric changes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC526194/
https://www.ncbi.nlm.nih.gov/pubmed/15462680
http://dx.doi.org/10.1186/1471-2482-4-13
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