Cargando…
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR
The Neurotransmitter:Sodium Symporters (NSSs) represent an important class of proteins mediating sodium-dependent uptake of neurotransmitters from the extracellular space. The substrate binding stoichiometry of the bacterial NSS protein, LeuT, and thus the principal transport mechanism, has been hea...
Autores principales: | Erlendsson, Simon, Gotfryd, Kamil, Larsen, Flemming Hofmann, Mortensen, Jonas Sigurd, Geiger, Michel-Andreas, van Rossum, Barth-Jan, Oschkinat, Hartmut, Gether, Ulrik, Teilum, Kaare, Loland, Claus J |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262378/ https://www.ncbi.nlm.nih.gov/pubmed/28117663 http://dx.doi.org/10.7554/eLife.19314 |
Ejemplares similares
-
Mechanism of the Association between Na(+) Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters
por: Stolzenberg, Sebastian, et al.
Publicado: (2015) -
The Environment Shapes the Inner Vestibule of LeuT
por: Sohail, Azmat, et al.
Publicado: (2016) -
Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT
por: Merkle, Patrick S., et al.
Publicado: (2018) -
Effect of Dimerization on the Dynamics of Neurotransmitter:Sodium
Symporters
por: Gur, Mert, et al.
Publicado: (2017) -
Substrate-dependent proton antiport in neurotransmitter:sodium symporters
por: Zhao, Yongfang, et al.
Publicado: (2009)