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The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach

CONTEXT: Reduced insulin sensitivity is one of the traditional risk factors for chronic diseases such as type 2 diabetes. Reduced insulin sensitivity leads to insulin resistance, which in turn can lead to the development of type 2 diabetes. Few studies have examined factors such as blood pressure, t...

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Autores principales: Skropanic, Dragan, Fufaa, Gudeta, Cai, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262434/
https://www.ncbi.nlm.nih.gov/pubmed/28123923
http://dx.doi.org/10.7759/cureus.942
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author Skropanic, Dragan
Fufaa, Gudeta
Cai, Bin
author_facet Skropanic, Dragan
Fufaa, Gudeta
Cai, Bin
author_sort Skropanic, Dragan
collection PubMed
description CONTEXT: Reduced insulin sensitivity is one of the traditional risk factors for chronic diseases such as type 2 diabetes. Reduced insulin sensitivity leads to insulin resistance, which in turn can lead to the development of type 2 diabetes. Few studies have examined factors such as blood pressure, tobacco and alcohol consumption that influence changes in insulin sensitivity over time especially among young adults. PURPOSE: To examine temporal changes in insulin sensitivity in young adults (18-30 years of age at baseline) over a period of 20 years by taking into account the effects of tobacco and alcohol consumptions at baseline. In other words, the purpose of the present study is to examine if baseline tobacco and alcohol consumptions can be used in predicting lowered insulin sensitivity. METHOD: This is a retrospective study using data collected by the Coronary Artery Risk Development in Young Adults (CARDIA) study from the National Heart, Lung, and Blood Institute. Participants were enrolled into the study in 1985 (baseline) and followed up to 2005. Insulin sensitivity, measured by the quantitative insulin sensitivity check index (QUICKI), was recorded at baseline and 20 years later, in 2005. The number of participants included in the study was 3,547. The original study included a total of 5,112 participants at baseline. Of these, 54.48% were female, and 45.52% were male; 45.31% were 18 to 24 years of age, and 54.69% were 25 to 30 years of age. Ordinal logistic regression was used to assess changes in insulin sensitivity. Changes in insulin sensitivity from baseline were calculated and grouped into three categories (more than 15%, more than 8.5% to at most 15%, and at most 8.5%), which provided the basis for employing ordinal logistic regression to assess changes in insulin sensitivity. The effects of alcohol and smoking consumption at baseline on the change in insulin sensitivity were accounted for by including these variables in the model. RESULTS: Daily alcohol consumption (ml/day) at baseline was not associated with changes in insulin sensitivity (OR = 0.998, 95% CI 0.995-1.001), while the number of cigarettes consumed per day at baseline was statistically significantly associated with changes in insulin sensitivity (OR = 1.016, 95% CI 1.007-1.025). Covariates such as age (OR = 1.05, 95% CI 1.031-1.071), mean arterial blood pressure (OR = 0.986, 95% CI 0.977-0.994), body-mass index (OR = 0.951, 95% CI 0.936-0.965), race (OR = 0.840, 95% CI 0.735-0.960), and sex (OR = 0.561, 95% CI 0.483-0.652) were significantly associated with changes in insulin sensitivity. CONCLUSION: After adjusting for relevant covariates, the daily tobacco consumption at baseline was independently associated with changes in insulin sensitivity. But we were not able to replicate the association between daily alcohol consumption at baseline and changes in insulin resistance reported by other studies. Further studies in different populations and settings are warranted to examine the association between alcohol consumption and changes in insulin resistance.
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spelling pubmed-52624342017-01-25 The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach Skropanic, Dragan Fufaa, Gudeta Cai, Bin Cureus Epidemiology/Public Health CONTEXT: Reduced insulin sensitivity is one of the traditional risk factors for chronic diseases such as type 2 diabetes. Reduced insulin sensitivity leads to insulin resistance, which in turn can lead to the development of type 2 diabetes. Few studies have examined factors such as blood pressure, tobacco and alcohol consumption that influence changes in insulin sensitivity over time especially among young adults. PURPOSE: To examine temporal changes in insulin sensitivity in young adults (18-30 years of age at baseline) over a period of 20 years by taking into account the effects of tobacco and alcohol consumptions at baseline. In other words, the purpose of the present study is to examine if baseline tobacco and alcohol consumptions can be used in predicting lowered insulin sensitivity. METHOD: This is a retrospective study using data collected by the Coronary Artery Risk Development in Young Adults (CARDIA) study from the National Heart, Lung, and Blood Institute. Participants were enrolled into the study in 1985 (baseline) and followed up to 2005. Insulin sensitivity, measured by the quantitative insulin sensitivity check index (QUICKI), was recorded at baseline and 20 years later, in 2005. The number of participants included in the study was 3,547. The original study included a total of 5,112 participants at baseline. Of these, 54.48% were female, and 45.52% were male; 45.31% were 18 to 24 years of age, and 54.69% were 25 to 30 years of age. Ordinal logistic regression was used to assess changes in insulin sensitivity. Changes in insulin sensitivity from baseline were calculated and grouped into three categories (more than 15%, more than 8.5% to at most 15%, and at most 8.5%), which provided the basis for employing ordinal logistic regression to assess changes in insulin sensitivity. The effects of alcohol and smoking consumption at baseline on the change in insulin sensitivity were accounted for by including these variables in the model. RESULTS: Daily alcohol consumption (ml/day) at baseline was not associated with changes in insulin sensitivity (OR = 0.998, 95% CI 0.995-1.001), while the number of cigarettes consumed per day at baseline was statistically significantly associated with changes in insulin sensitivity (OR = 1.016, 95% CI 1.007-1.025). Covariates such as age (OR = 1.05, 95% CI 1.031-1.071), mean arterial blood pressure (OR = 0.986, 95% CI 0.977-0.994), body-mass index (OR = 0.951, 95% CI 0.936-0.965), race (OR = 0.840, 95% CI 0.735-0.960), and sex (OR = 0.561, 95% CI 0.483-0.652) were significantly associated with changes in insulin sensitivity. CONCLUSION: After adjusting for relevant covariates, the daily tobacco consumption at baseline was independently associated with changes in insulin sensitivity. But we were not able to replicate the association between daily alcohol consumption at baseline and changes in insulin resistance reported by other studies. Further studies in different populations and settings are warranted to examine the association between alcohol consumption and changes in insulin resistance. Cureus 2016-12-24 /pmc/articles/PMC5262434/ /pubmed/28123923 http://dx.doi.org/10.7759/cureus.942 Text en Copyright © 2016, Skropanic et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Epidemiology/Public Health
Skropanic, Dragan
Fufaa, Gudeta
Cai, Bin
The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach
title The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach
title_full The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach
title_fullStr The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach
title_full_unstemmed The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach
title_short The Association Between Changes in Insulin Sensitivity and Consumption of Tobacco and Alcohol in Young Adults: Ordinal Logistic Regression Approach
title_sort association between changes in insulin sensitivity and consumption of tobacco and alcohol in young adults: ordinal logistic regression approach
topic Epidemiology/Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262434/
https://www.ncbi.nlm.nih.gov/pubmed/28123923
http://dx.doi.org/10.7759/cureus.942
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