Cargando…

A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder

BACKGROUND: Genome-wide association studies (GWASs) of major depressive disorder (MDD) have identified few significant associations. Testing the aggregation of genetic variants, in particular biological pathways, may be more powerful. Regional heritability analysis can be used to detect genomic regi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Yanni, Navarro, Pau, Fernandez-Pujals, Ana M., Hall, Lynsey S., Clarke, Toni-Kim, Thomson, Pippa A., Smith, Blair H., Hocking, Lynne J., Padmanabhan, Sandosh, Hayward, Caroline, MacIntyre, Donald J., Wray, Naomi R., Deary, Ian J., Porteous, David J., Haley, Chris S., McIntosh, Andrew M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Archival Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262437/ https://www.ncbi.nlm.nih.gov/pubmed/27422368 http://dx.doi.org/10.1016/j.biopsych.2016.04.017

Ejemplares similares

Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population‐based cohort
por: Clarke, Toni‐Kim, et al.
Publicado: (2015)

Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression
por: Zeng, Yanni, et al.
Publicado: (2016)

Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort
por: Clarke, Toni‐Kim, et al.
Publicado: (2016)

Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index
por: Clarke, T-K, et al.
Publicado: (2015)

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism
por: Clarke, Toni-Kim, et al.
Publicado: (2019)

Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder
por: Zeng, Yanni, et al.
Publicado: (2017)

Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS)
por: Fernandez-Pujals, Ana Maria, et al.
Publicado: (2015)

Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank
por: Barbu, Miruna C., et al.
Publicado: (2019)

SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): Joint Mapping of Common and Rare Variation Affecting Complex Traits
por: Oppong, Richard F., et al.
Publicado: (2022)

Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium()
por: Power, Robert A., et al.
Publicado: (2017)

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank
por: Hall, Lynsey S., et al.
Publicado: (2018)

Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP
por: Wigmore, Eleanor M., et al.
Publicado: (2019)

Insulin resistance: Genetic associations with depression and cognition in population based cohorts
por: Frangou, Sophia, et al.
Publicado: (2019)

Pathway-Based Polygenic Risk Scores for Schizophrenia and Associations With Reported Psychotic-like Experiences and Neuroimaging Phenotypes in the UK Biobank
por: Barbu, Miruna C., et al.
Publicado: (2023)

Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment
por: ter Kuile, Abigail R., et al.
Publicado: (2023)

Polygenic risk for coronary artery disease is associated with cognitive ability in older adults
por: Hagenaars, Saskia P, et al.
Publicado: (2016)

Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis
por: McIntosh, Andrew M., et al.
Publicado: (2016)

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population
por: Clarke, T-K, et al.
Publicado: (2016)

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population
por: Clarke, Toni-Kim, et al.
Publicado: (2019)

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank
por: Howard, David M., et al.
Publicado: (2017)

Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766)
por: Wigmore, E M, et al.
Publicado: (2017)

Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study
por: van Hecke, Oliver, et al.
Publicado: (2017)

Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants
por: Nagy, Reka, et al.
Publicado: (2017)

Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression
por: McIntosh, Andrew M., et al.
Publicado: (2012)

Identifying the Common Genetic Basis of Antidepressant Response
por: Pain, Oliver, et al.
Publicado: (2021)

Genomic analysis of family data reveals additional genetic effects on intelligence and personality
por: Hill, W. David, et al.
Publicado: (2018)

Genome-wide methylation data improves dissection of the effect of smoking on body mass index
por: Amador, Carmen, et al.
Publicado: (2021)

Haplotype Heritability Mapping Method Uncovers Missing Heritability of Complex Traits
por: Shirali, Masoud, et al.
Publicado: (2018)

A validation of the diathesis-stress model for depression in Generation Scotland
por: Arnau-Soler, Aleix, et al.
Publicado: (2019)

Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): a questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS)
por: Navrady, L B, et al.
Publicado: (2018)

Molecular genetic contributions to socioeconomic status and intelligence
por: Marioni, Riccardo E., et al.
Publicado: (2014)

DISC1 and Huntington's Disease – Overlapping Pathways of Vulnerability to Neurological Disorder?
por: Boxall, Ruth, et al.
Publicado: (2011)

Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the Generalized Singular Value Decomposition
por: Xiao, Xiaolin, et al.
Publicado: (2011)

Investigating Direct and Indirect Genetic Effects in Attention-Deficit/Hyperactivity Disorder Using Parent-Offspring Trios
por: Martin, Joanna, et al.
Publicado: (2023)

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts
por: Whalley, H C, et al.
Publicado: (2016)

NF-κB Signaling in Tumor Pathways Focusing on Breast and Ovarian Cancer
por: Devanaboyina, Monika, et al.
Publicado: (2022)

Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data
por: Gibson, J, et al.
Publicado: (2017)

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
por: Clarke, T-K, et al.
Publicado: (2017)

Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank
por: Howard, David M., et al.
Publicado: (2017)

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
por: Arnau-Soler, Aleix, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_agfikb68toku7idkmnv73r0kdm