Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report

A 58-year-old woman with lung cancer complaint odynophagia by sour food. Endoscopic examination revealed severe erosion strictly limited to the esophagus. Drug-induced esophagitis was suspected. She was taking afatinib, loxoprofen, pregabalin, lorazepam, a formulation of butyric acid bacteria, and a...

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Autores principales: Inoue, Takako, Kimura, Madoka, Tamiya, Motohiro, Nishino, Kazumi, Kumagai, Toru, Imamura, Fumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262501/
https://www.ncbi.nlm.nih.gov/pubmed/28149745
http://dx.doi.org/10.1016/j.rmcr.2017.01.009
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author Inoue, Takako
Kimura, Madoka
Tamiya, Motohiro
Nishino, Kazumi
Kumagai, Toru
Imamura, Fumio
author_facet Inoue, Takako
Kimura, Madoka
Tamiya, Motohiro
Nishino, Kazumi
Kumagai, Toru
Imamura, Fumio
author_sort Inoue, Takako
collection PubMed
description A 58-year-old woman with lung cancer complaint odynophagia by sour food. Endoscopic examination revealed severe erosion strictly limited to the esophagus. Drug-induced esophagitis was suspected. She was taking afatinib, loxoprofen, pregabalin, lorazepam, a formulation of butyric acid bacteria, and amino acid supplements for more than 1 month at the time of developing esophagitis. Her appetite was very poor for several days before developing the esophagitis. Although not definitive, the most probable cause of her esophagitis is an increased blood concentration of afatinib due to prolonged starved condition.
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spelling pubmed-52625012017-02-01 Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report Inoue, Takako Kimura, Madoka Tamiya, Motohiro Nishino, Kazumi Kumagai, Toru Imamura, Fumio Respir Med Case Rep Case Report A 58-year-old woman with lung cancer complaint odynophagia by sour food. Endoscopic examination revealed severe erosion strictly limited to the esophagus. Drug-induced esophagitis was suspected. She was taking afatinib, loxoprofen, pregabalin, lorazepam, a formulation of butyric acid bacteria, and amino acid supplements for more than 1 month at the time of developing esophagitis. Her appetite was very poor for several days before developing the esophagitis. Although not definitive, the most probable cause of her esophagitis is an increased blood concentration of afatinib due to prolonged starved condition. Elsevier 2017-01-19 /pmc/articles/PMC5262501/ /pubmed/28149745 http://dx.doi.org/10.1016/j.rmcr.2017.01.009 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Inoue, Takako
Kimura, Madoka
Tamiya, Motohiro
Nishino, Kazumi
Kumagai, Toru
Imamura, Fumio
Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report
title Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report
title_full Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report
title_fullStr Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report
title_full_unstemmed Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report
title_short Afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: A case report
title_sort afatinib-induced severe esophagitis in a lung cancer patient with an activated epidermal growth factor receptor mutation: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262501/
https://www.ncbi.nlm.nih.gov/pubmed/28149745
http://dx.doi.org/10.1016/j.rmcr.2017.01.009
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