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Intra-tumor delivery of zoledronate mitigates metastasis-induced osteolysis superior to systemic administration
Bisphosphonates (BPs) have recently been shown to have direct anti-tumor properties. Systemic treatment with BPs can have multiple adverse effects such as osteonecrosis of the jaw and BP induced bone fracturing and spine instability. While benefits of systemic BP treatments may outweigh risks, local...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5262502/ https://www.ncbi.nlm.nih.gov/pubmed/28138422 http://dx.doi.org/10.1016/j.jbo.2017.01.001 |