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Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging

Low-complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized,...

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Detalles Bibliográficos
Autores principales:	Lechler, Marie C., Crawford, Emily D., Groh, Nicole, Widmaier, Katja, Jung, Raimund, Kirstein, Janine, Trinidad, Jonathan C., Burlingame, Alma L., David, Della C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263236/ https://www.ncbi.nlm.nih.gov/pubmed/28076789 http://dx.doi.org/10.1016/j.celrep.2016.12.033

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