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Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme

Adaptation of feathered dinosaurs and Mesozoic birds to new ecological niches was potentiated by rapid diversification of feather vane shapes. The molecular mechanism driving this spectacular process remains unclear. Here, through morphology analysis, transcriptome profiling, functional perturbation...

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Autores principales: Li, Ang, Figueroa, Seth, Jiang, Ting-Xin, Wu, Ping, Widelitz, Randall, Nie, Qing, Chuong, Cheng-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263876/
https://www.ncbi.nlm.nih.gov/pubmed/28106042
http://dx.doi.org/10.1038/ncomms14139
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author Li, Ang
Figueroa, Seth
Jiang, Ting-Xin
Wu, Ping
Widelitz, Randall
Nie, Qing
Chuong, Cheng-Ming
author_facet Li, Ang
Figueroa, Seth
Jiang, Ting-Xin
Wu, Ping
Widelitz, Randall
Nie, Qing
Chuong, Cheng-Ming
author_sort Li, Ang
collection PubMed
description Adaptation of feathered dinosaurs and Mesozoic birds to new ecological niches was potentiated by rapid diversification of feather vane shapes. The molecular mechanism driving this spectacular process remains unclear. Here, through morphology analysis, transcriptome profiling, functional perturbations and mathematical simulations, we find that mesenchyme-derived GDF10 and GREM1 are major controllers for the topologies of rachidial and barb generative zones (setting vane boundaries), respectively, by tuning the periodic-branching programme of epithelial progenitors. Their interactions with the anterior–posterior WNT gradient establish the bilateral-symmetric vane configuration. Additionally, combinatory effects of CYP26B1, CRABP1 and RALDH3 establish dynamic retinoic acid (RA) landscapes in feather mesenchyme, which modulate GREM1 expression and epithelial cell shapes. Incremental changes of RA gradient slopes establish a continuum of asymmetric flight feathers along the wing, while switch-like modulation of RA signalling confers distinct vane shapes between feather tracts. Therefore, the co-option of anisotropic signalling modules introduced new dimensions of feather shape diversification.
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spelling pubmed-52638762017-02-03 Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme Li, Ang Figueroa, Seth Jiang, Ting-Xin Wu, Ping Widelitz, Randall Nie, Qing Chuong, Cheng-Ming Nat Commun Article Adaptation of feathered dinosaurs and Mesozoic birds to new ecological niches was potentiated by rapid diversification of feather vane shapes. The molecular mechanism driving this spectacular process remains unclear. Here, through morphology analysis, transcriptome profiling, functional perturbations and mathematical simulations, we find that mesenchyme-derived GDF10 and GREM1 are major controllers for the topologies of rachidial and barb generative zones (setting vane boundaries), respectively, by tuning the periodic-branching programme of epithelial progenitors. Their interactions with the anterior–posterior WNT gradient establish the bilateral-symmetric vane configuration. Additionally, combinatory effects of CYP26B1, CRABP1 and RALDH3 establish dynamic retinoic acid (RA) landscapes in feather mesenchyme, which modulate GREM1 expression and epithelial cell shapes. Incremental changes of RA gradient slopes establish a continuum of asymmetric flight feathers along the wing, while switch-like modulation of RA signalling confers distinct vane shapes between feather tracts. Therefore, the co-option of anisotropic signalling modules introduced new dimensions of feather shape diversification. Nature Publishing Group 2017-01-20 /pmc/articles/PMC5263876/ /pubmed/28106042 http://dx.doi.org/10.1038/ncomms14139 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Ang
Figueroa, Seth
Jiang, Ting-Xin
Wu, Ping
Widelitz, Randall
Nie, Qing
Chuong, Cheng-Ming
Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme
title Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme
title_full Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme
title_fullStr Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme
title_full_unstemmed Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme
title_short Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme
title_sort diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263876/
https://www.ncbi.nlm.nih.gov/pubmed/28106042
http://dx.doi.org/10.1038/ncomms14139
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