Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats) mediated genome editing is a powerful approach for loss of function studies. Here we report that lentiviral CRISPR/Cas9 vectors are highly efficient in introducing mutations in the precursor miRNA sequence, thus leading to the l...

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Detalles Bibliográficos
Autores principales: Huo, Wenying, Zhao, Guannan, Yin, Jinggang, Ouyang, Xuan, Wang, Yinan, Yang, Chuanhe, Wang, Baojing, Dong, Peixin, Wang, Zhixiang, Watari, Hidemichi, Chaum, Edward, Pfeffer, Lawrence M., Yue, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264040/
https://www.ncbi.nlm.nih.gov/pubmed/28123598
http://dx.doi.org/10.7150/jca.16723

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