Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model

OBJECTIVE: To investigate whether the effects of nerve growth factor (NGF) inhibition with tanezumab on rats with medial meniscal tear (MMT) effectively model rapidly progressive osteoarthritis (RPOA) observed in clinical trials. METHODS: Male Lewis rats underwent MMT surgery and were treated weekly...

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Detalles Bibliográficos
Autores principales: LaBranche, Timothy P, Bendele, Alison M, Omura, Brian C, Gropp, Kathryn E, Hurst, Susan I, Bagi, Cedo M, Cummings, Thomas R, Grantham, Lonnie E, Shelton, David L, Zorbas, Mark A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264211/
https://www.ncbi.nlm.nih.gov/pubmed/27381034
http://dx.doi.org/10.1136/annrheumdis-2015-208913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264211/
https://www.ncbi.nlm.nih.gov/pubmed/27381034
http://dx.doi.org/10.1136/annrheumdis-2015-208913

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