Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis

The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secretion from normal cells in mice and cancer patients in a clini...

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Detalles Bibliográficos
Autores principales: Burikhanov, Ravshan, Hebbar, Nikhil, Noothi, Sunil K., Shukla, Nidhi, Sledziona, James, Araujo, Nathália, Kudrimoti, Meghana, Wang, Qing Jun, Watt, David S., Welch, Danny R., Maranchie, Jodi, Harada, Akihiro, Rangnekar, Vivek M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264245/
https://www.ncbi.nlm.nih.gov/pubmed/28076793
http://dx.doi.org/10.1016/j.celrep.2016.12.051

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