Ubiquitin-specific Protease-7 Inhibition Impairs Tip60-dependent Foxp3 + T-regulatory Cell Function and Promotes Antitumor Immunity

Foxp3 + T-regulatory (Treg) cells are known to suppress protective host immune responses to a wide variety of solid tumors, but their therapeutic targeting is largely restricted to their transient depletion or “secondary” modulation, e.g. using anti-CTLA-4 monoclonal antibody. Our ongoing studies of...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Liqing, Kumar, Suresh, Dahiya, Satinder, Wang, Feng, Wu, Jian, Newick, Kheng, Han, Rongxiang, Samanta, Arabinda, Beier, Ulf H., Akimova, Tatiana, Bhatti, Tricia R., Nicholson, Benjamin, Kodrasov, Mathew P., Agarwal, Saket, Sterner, David E., Gu, Wei, Weinstock, Joseph, Butt, Tauseef R., Albelda, Steven M., Hancock, Wayne W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264272/
https://www.ncbi.nlm.nih.gov/pubmed/27769803
http://dx.doi.org/10.1016/j.ebiom.2016.10.018

Ejemplares similares

Ejemplares similares