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Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7

BACKGROUND: Toll-like receptor (TLR) signaling is emerging as an important component of neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate innate immune responses leading to neurodegeneration. Alcoholism is associated with hippocampal degeneration, with preclinical st...

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Detalles Bibliográficos
Autores principales:	Coleman, Leon G., Zou, Jian, Crews, Fulton T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264311/ https://www.ncbi.nlm.nih.gov/pubmed/28118842 http://dx.doi.org/10.1186/s12974-017-0799-4

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