MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR...

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Detalles Bibliográficos
Autores principales: Li, Pei, Yang, Yang, Liu, Hui, Yang, An-Kui, Di, Jin-Ming, Tan, Guang-Mou, Wang, Hai-Feng, Qiu, Jian-Ge, Zhang, Wen-Ji, Jiang, Qi-Wei, Zheng, Di-Wei, Chen, Yao, Wei, Meng-Ning, Huang, Jia-Rong, Wang, Kun, Shi, Zhi, Ye, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264457/
https://www.ncbi.nlm.nih.gov/pubmed/28122647
http://dx.doi.org/10.1186/s13045-017-0402-6
Descripción
Sumario:The emerging roles of microRNAs (miRs) have been deeply investigated in cancer. However, the role of miR-194 in human laryngeal squamous cell carcinoma (LSCC) is still unclear. Here, we have demonstrated that miR-194 is significantly downregulated in LSCC tissues and cells, and overexpression of miR-194 inhibits the proliferation, migration, invasion, and drug resistance in LSCC cells. Moreover, Wee1 is identified as a novel direct target of miR-194. Ectopic expression of Wee1 at least in part overcomes the suppressive impacts of miR-194 on the malignant phenotypes of LSCC. Overall, our study provides new sights into the role of miR-194/Wee1 axis in LSCC and suggests a novel miR-194/Wee1-based clinical application for LSCC patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-017-0402-6) contains supplementary material, which is available to authorized users.

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