Allele-specific analysis of cell fusion-mediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation

BACKGROUND: Inactivation of one X chromosome is established early in female mammalian development and can be reversed in vivo and in vitro when pluripotency factors are re-expressed. The extent of reactivation along the inactive X chromosome (Xi) and the determinants of locus susceptibility are, how...

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Detalles Bibliográficos
Autores principales: Cantone, Irene, Dharmalingam, Gopuraja, Chan, Yi-Wah, Kohler, Anne-Celine, Lenhard, Boris, Merkenschlager, Matthias, Fisher, Amanda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264468/
https://www.ncbi.nlm.nih.gov/pubmed/28118853
http://dx.doi.org/10.1186/s13059-016-1136-4

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