ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

SMSr/SAMD8 is an ER-resident ceramide phosphoethanolamine synthase with a critical role in controlling ER ceramides and suppressing ceramide-induced apoptosis in cultured cells. SMSr-mediated ceramide homeostasis relies on the enzyme’s catalytic activity as well as on its N-terminal sterile α-motif...

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Detalles Bibliográficos
Autores principales: Cabukusta, Birol, Kol, Matthijs, Kneller, Laura, Hilderink, Angelika, Bickert, Andreas, Mina, John G. M., Korneev, Sergei, Holthuis, Joost C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264588/
https://www.ncbi.nlm.nih.gov/pubmed/28120887
http://dx.doi.org/10.1038/srep41290

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