The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence

Cyclin-dependent kinase inhibitor p16(INK4a) (p16) primarily functions as a negative regulator of the retinoblastoma protein (Rb) -E2F pathway, thus plays critical role in cell cycle progression, cellular senescence and apoptosis. In this study, we showed that the methylation of Arg 138 and the phos...

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Detalles Bibliográficos
Autores principales: Lu, Yang, Ma, Wenlong, Li, Zhongwei, Lu, Jun, Wang, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264599/
https://www.ncbi.nlm.nih.gov/pubmed/28120917
http://dx.doi.org/10.1038/srep41390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264599/
https://www.ncbi.nlm.nih.gov/pubmed/28120917
http://dx.doi.org/10.1038/srep41390

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