Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress

Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base variations measuring up to 0.48% of the total variation...

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Detalles Bibliográficos
Autores principales: Sharma, Anchal, Ansari, Asgar Hussain, Kumari, Renu, Pandey, Rajesh, Rehman, Rakhshinda, Mehani, Bharati, Varma, Binuja, Desiraju, Bapu K., Mabalirajan, Ulaganathan, Agrawal, Anurag, Mukhopadhyay, Arijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265704/
https://www.ncbi.nlm.nih.gov/pubmed/28149503
http://dx.doi.org/10.12688/f1000research.9495.3

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