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Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study

This study aimed to investigate the clinicopathological characteristics and survival outcomes of the subclassification of pT2 gastric cancers according to the depth of tumor involvement. We retrospectively collected clinicopathological data and survival outcomes for pT2 gastric cancer patients from...

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Autores principales: Zhang, Wei-Han, He, Du, Chen, Dan-Ni, Li, Ting-Ting, Chen, Xin-Zu, Yang, Kun, Liu, Kai, Zhang, Bo, Chen, Zhi-Xin, Zhou, Zong-Guang, Hu, Jian Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265755/
https://www.ncbi.nlm.nih.gov/pubmed/27442638
http://dx.doi.org/10.1097/MD.0000000000004165
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author Zhang, Wei-Han
He, Du
Chen, Dan-Ni
Li, Ting-Ting
Chen, Xin-Zu
Yang, Kun
Liu, Kai
Zhang, Bo
Chen, Zhi-Xin
Zhou, Zong-Guang
Hu, Jian Kun
author_facet Zhang, Wei-Han
He, Du
Chen, Dan-Ni
Li, Ting-Ting
Chen, Xin-Zu
Yang, Kun
Liu, Kai
Zhang, Bo
Chen, Zhi-Xin
Zhou, Zong-Guang
Hu, Jian Kun
author_sort Zhang, Wei-Han
collection PubMed
description This study aimed to investigate the clinicopathological characteristics and survival outcomes of the subclassification of pT2 gastric cancers according to the depth of tumor involvement. We retrospectively collected clinicopathological data and survival outcomes for pT2 gastric cancer patients from 2006 to 2011. Patients were classified into the superficial muscularis propria (sMP) and deep muscularis propria (dMP) groups. Eighty-nine patients had sMP gastric cancers and 90 patients had dMP gastric cancers. The rates of lymph node metastasis for the sMP and dMP groups were 55.1% and 64.4%, respectively, P = 0.202. The 5-year overall survival (OS) of patients in the sMP group was significantly better than patients in the dMP group (76% vs 61%, P = 0.018). Multivariate analysis demonstrated that the depth of tumor invasion, lymph node metastasis, and postoperative chemotherapy were prognostic risk factors for the OS. For patients with pN0 stage tumor(s), the sMP group had a significantly better 5-year OS rate than the dMP group (92% vs 62%, P = 0.004); for patients with pN1–N3 stages, the 5-year OS rates were comparable between the sMP and dMP groups (64% vs 61%, P = 0.540). The subclassification of pT2 gastric cancer into the sMP and dMP groups can demonstrate different survival outcomes according to the lymph node status. However, the pT2 stage subclassification in the next tumor, node, metastasis (TNM) staging system is pending and requires more large sample size studies to confirm its importance.
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spelling pubmed-52657552017-02-03 Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study Zhang, Wei-Han He, Du Chen, Dan-Ni Li, Ting-Ting Chen, Xin-Zu Yang, Kun Liu, Kai Zhang, Bo Chen, Zhi-Xin Zhou, Zong-Guang Hu, Jian Kun Medicine (Baltimore) 7100 This study aimed to investigate the clinicopathological characteristics and survival outcomes of the subclassification of pT2 gastric cancers according to the depth of tumor involvement. We retrospectively collected clinicopathological data and survival outcomes for pT2 gastric cancer patients from 2006 to 2011. Patients were classified into the superficial muscularis propria (sMP) and deep muscularis propria (dMP) groups. Eighty-nine patients had sMP gastric cancers and 90 patients had dMP gastric cancers. The rates of lymph node metastasis for the sMP and dMP groups were 55.1% and 64.4%, respectively, P = 0.202. The 5-year overall survival (OS) of patients in the sMP group was significantly better than patients in the dMP group (76% vs 61%, P = 0.018). Multivariate analysis demonstrated that the depth of tumor invasion, lymph node metastasis, and postoperative chemotherapy were prognostic risk factors for the OS. For patients with pN0 stage tumor(s), the sMP group had a significantly better 5-year OS rate than the dMP group (92% vs 62%, P = 0.004); for patients with pN1–N3 stages, the 5-year OS rates were comparable between the sMP and dMP groups (64% vs 61%, P = 0.540). The subclassification of pT2 gastric cancer into the sMP and dMP groups can demonstrate different survival outcomes according to the lymph node status. However, the pT2 stage subclassification in the next tumor, node, metastasis (TNM) staging system is pending and requires more large sample size studies to confirm its importance. Wolters Kluwer Health 2016-07-22 /pmc/articles/PMC5265755/ /pubmed/27442638 http://dx.doi.org/10.1097/MD.0000000000004165 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 7100
Zhang, Wei-Han
He, Du
Chen, Dan-Ni
Li, Ting-Ting
Chen, Xin-Zu
Yang, Kun
Liu, Kai
Zhang, Bo
Chen, Zhi-Xin
Zhou, Zong-Guang
Hu, Jian Kun
Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study
title Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study
title_full Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study
title_fullStr Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study
title_full_unstemmed Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study
title_short Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study
title_sort comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: a retrospective cohort study
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265755/
https://www.ncbi.nlm.nih.gov/pubmed/27442638
http://dx.doi.org/10.1097/MD.0000000000004165
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