Cargando…
Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study
This study aimed to investigate the clinicopathological characteristics and survival outcomes of the subclassification of pT2 gastric cancers according to the depth of tumor involvement. We retrospectively collected clinicopathological data and survival outcomes for pT2 gastric cancer patients from...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265755/ https://www.ncbi.nlm.nih.gov/pubmed/27442638 http://dx.doi.org/10.1097/MD.0000000000004165 |
_version_ | 1782500329063972864 |
---|---|
author | Zhang, Wei-Han He, Du Chen, Dan-Ni Li, Ting-Ting Chen, Xin-Zu Yang, Kun Liu, Kai Zhang, Bo Chen, Zhi-Xin Zhou, Zong-Guang Hu, Jian Kun |
author_facet | Zhang, Wei-Han He, Du Chen, Dan-Ni Li, Ting-Ting Chen, Xin-Zu Yang, Kun Liu, Kai Zhang, Bo Chen, Zhi-Xin Zhou, Zong-Guang Hu, Jian Kun |
author_sort | Zhang, Wei-Han |
collection | PubMed |
description | This study aimed to investigate the clinicopathological characteristics and survival outcomes of the subclassification of pT2 gastric cancers according to the depth of tumor involvement. We retrospectively collected clinicopathological data and survival outcomes for pT2 gastric cancer patients from 2006 to 2011. Patients were classified into the superficial muscularis propria (sMP) and deep muscularis propria (dMP) groups. Eighty-nine patients had sMP gastric cancers and 90 patients had dMP gastric cancers. The rates of lymph node metastasis for the sMP and dMP groups were 55.1% and 64.4%, respectively, P = 0.202. The 5-year overall survival (OS) of patients in the sMP group was significantly better than patients in the dMP group (76% vs 61%, P = 0.018). Multivariate analysis demonstrated that the depth of tumor invasion, lymph node metastasis, and postoperative chemotherapy were prognostic risk factors for the OS. For patients with pN0 stage tumor(s), the sMP group had a significantly better 5-year OS rate than the dMP group (92% vs 62%, P = 0.004); for patients with pN1–N3 stages, the 5-year OS rates were comparable between the sMP and dMP groups (64% vs 61%, P = 0.540). The subclassification of pT2 gastric cancer into the sMP and dMP groups can demonstrate different survival outcomes according to the lymph node status. However, the pT2 stage subclassification in the next tumor, node, metastasis (TNM) staging system is pending and requires more large sample size studies to confirm its importance. |
format | Online Article Text |
id | pubmed-5265755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-52657552017-02-03 Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study Zhang, Wei-Han He, Du Chen, Dan-Ni Li, Ting-Ting Chen, Xin-Zu Yang, Kun Liu, Kai Zhang, Bo Chen, Zhi-Xin Zhou, Zong-Guang Hu, Jian Kun Medicine (Baltimore) 7100 This study aimed to investigate the clinicopathological characteristics and survival outcomes of the subclassification of pT2 gastric cancers according to the depth of tumor involvement. We retrospectively collected clinicopathological data and survival outcomes for pT2 gastric cancer patients from 2006 to 2011. Patients were classified into the superficial muscularis propria (sMP) and deep muscularis propria (dMP) groups. Eighty-nine patients had sMP gastric cancers and 90 patients had dMP gastric cancers. The rates of lymph node metastasis for the sMP and dMP groups were 55.1% and 64.4%, respectively, P = 0.202. The 5-year overall survival (OS) of patients in the sMP group was significantly better than patients in the dMP group (76% vs 61%, P = 0.018). Multivariate analysis demonstrated that the depth of tumor invasion, lymph node metastasis, and postoperative chemotherapy were prognostic risk factors for the OS. For patients with pN0 stage tumor(s), the sMP group had a significantly better 5-year OS rate than the dMP group (92% vs 62%, P = 0.004); for patients with pN1–N3 stages, the 5-year OS rates were comparable between the sMP and dMP groups (64% vs 61%, P = 0.540). The subclassification of pT2 gastric cancer into the sMP and dMP groups can demonstrate different survival outcomes according to the lymph node status. However, the pT2 stage subclassification in the next tumor, node, metastasis (TNM) staging system is pending and requires more large sample size studies to confirm its importance. Wolters Kluwer Health 2016-07-22 /pmc/articles/PMC5265755/ /pubmed/27442638 http://dx.doi.org/10.1097/MD.0000000000004165 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 7100 Zhang, Wei-Han He, Du Chen, Dan-Ni Li, Ting-Ting Chen, Xin-Zu Yang, Kun Liu, Kai Zhang, Bo Chen, Zhi-Xin Zhou, Zong-Guang Hu, Jian Kun Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study |
title | Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study |
title_full | Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study |
title_fullStr | Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study |
title_full_unstemmed | Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study |
title_short | Comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: A retrospective cohort study |
title_sort | comparison between superficial muscularis propria and deep muscularis propria infiltration in gastric cancer patients: a retrospective cohort study |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265755/ https://www.ncbi.nlm.nih.gov/pubmed/27442638 http://dx.doi.org/10.1097/MD.0000000000004165 |
work_keys_str_mv | AT zhangweihan comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT hedu comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT chendanni comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT litingting comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT chenxinzu comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT yangkun comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT liukai comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT zhangbo comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT chenzhixin comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT zhouzongguang comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy AT hujiankun comparisonbetweensuperficialmuscularispropriaanddeepmuscularispropriainfiltrationingastriccancerpatientsaretrospectivecohortstudy |