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Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men

Serum lipocalin-2 (LCN2) plays an important role in the regulation of the obesity-associated dysmetabolic state and cardiovascular disease. However, relatively little is known about the relationship between serum LCN2 levels and body fat content and distribution. We examined the associations of tota...

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Autores principales: Luo, Yuqi, Ma, Xiaojing, Pan, Xiaoping, Xu, Yiting, Xiong, Qin, Xiao, Yunfeng, Bao, Yuqian, Jia, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265815/
https://www.ncbi.nlm.nih.gov/pubmed/27472678
http://dx.doi.org/10.1097/MD.0000000000004039
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author Luo, Yuqi
Ma, Xiaojing
Pan, Xiaoping
Xu, Yiting
Xiong, Qin
Xiao, Yunfeng
Bao, Yuqian
Jia, Weiping
author_facet Luo, Yuqi
Ma, Xiaojing
Pan, Xiaoping
Xu, Yiting
Xiong, Qin
Xiao, Yunfeng
Bao, Yuqian
Jia, Weiping
author_sort Luo, Yuqi
collection PubMed
description Serum lipocalin-2 (LCN2) plays an important role in the regulation of the obesity-associated dysmetabolic state and cardiovascular disease. However, relatively little is known about the relationship between serum LCN2 levels and body fat content and distribution. We examined the associations of total body fat content and abdominal fat distribution with serum LCN2 levels in Chinese men. The study was based on a cross-sectional analysis of data for 1203 Chinese men aged 22 to 78 years from the Shanghai Obesity Study. Body fat percentage (fat%) was assessed by bioelectrical impedance analysis, and magnetic resonance imaging was adopted to quantify the visceral fat area (VFA) and subcutaneous fat area (SFA). Serum levels of LCN2 were measured with a standard enzyme-linked immunosorbent assay method. Subjects with a high fat% had higher serum LCN2 levels than those with a normal fat% regardless of their body mass index category (<25 and ≥25 kg/m(2)). The frequency of isolated high VFA was increased with increasing quintiles of serum LCN2 levels (P < 0.001), but the frequency of isolated high SFA did not differ between quintiles of serum LCN2 levels. A trend of increasing VFA was observed with increasing serum LCN2 levels (P < 0.001). Multiple stepwise regression analysis showed that VFA was positively associated with serum LCN2 levels, independent of overall obesity and other confounding factors (standardized β = 0.082, P = 0.008). Serum LCN2 levels are positively correlated with body fat content and independently associated with VFA in Chinese men.
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spelling pubmed-52658152017-02-03 Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men Luo, Yuqi Ma, Xiaojing Pan, Xiaoping Xu, Yiting Xiong, Qin Xiao, Yunfeng Bao, Yuqian Jia, Weiping Medicine (Baltimore) 4400 Serum lipocalin-2 (LCN2) plays an important role in the regulation of the obesity-associated dysmetabolic state and cardiovascular disease. However, relatively little is known about the relationship between serum LCN2 levels and body fat content and distribution. We examined the associations of total body fat content and abdominal fat distribution with serum LCN2 levels in Chinese men. The study was based on a cross-sectional analysis of data for 1203 Chinese men aged 22 to 78 years from the Shanghai Obesity Study. Body fat percentage (fat%) was assessed by bioelectrical impedance analysis, and magnetic resonance imaging was adopted to quantify the visceral fat area (VFA) and subcutaneous fat area (SFA). Serum levels of LCN2 were measured with a standard enzyme-linked immunosorbent assay method. Subjects with a high fat% had higher serum LCN2 levels than those with a normal fat% regardless of their body mass index category (<25 and ≥25 kg/m(2)). The frequency of isolated high VFA was increased with increasing quintiles of serum LCN2 levels (P < 0.001), but the frequency of isolated high SFA did not differ between quintiles of serum LCN2 levels. A trend of increasing VFA was observed with increasing serum LCN2 levels (P < 0.001). Multiple stepwise regression analysis showed that VFA was positively associated with serum LCN2 levels, independent of overall obesity and other confounding factors (standardized β = 0.082, P = 0.008). Serum LCN2 levels are positively correlated with body fat content and independently associated with VFA in Chinese men. Wolters Kluwer Health 2016-07-29 /pmc/articles/PMC5265815/ /pubmed/27472678 http://dx.doi.org/10.1097/MD.0000000000004039 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 4400
Luo, Yuqi
Ma, Xiaojing
Pan, Xiaoping
Xu, Yiting
Xiong, Qin
Xiao, Yunfeng
Bao, Yuqian
Jia, Weiping
Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men
title Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men
title_full Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men
title_fullStr Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men
title_full_unstemmed Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men
title_short Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men
title_sort serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in chinese men
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265815/
https://www.ncbi.nlm.nih.gov/pubmed/27472678
http://dx.doi.org/10.1097/MD.0000000000004039
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