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A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy
INTRODUCTION: Synovial sarcoma is a malignant soft tissue sarcoma which arises near joints. The most frequent metastasis sites of synovial sarcoma are the lungs, lymph nodes, and bone. Pancreatic metastasis is quite rare; only 3 cases have been reported worldwide to date. We herein present the 4th c...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265897/ https://www.ncbi.nlm.nih.gov/pubmed/27684804 http://dx.doi.org/10.1097/MD.0000000000004789 |
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author | Makino, Yuki Shigekawa, Minoru Kegasawa, Tadashi Suda, Takahiro Yoshioka, Teppei Iwahashi, Kiyoshi Ikezawa, Kenji Sakamori, Ryotaro Yakushijin, Takayuki Kajihara, Jun Tomimaru, Yoshito Eguchi, Hidetoshi Imura, Yoshinori Outani, Hidetatsu Naka, Norifumi Honma, Keiichiro Morii, Eiichi Tatsumi, Tomohide Hiramatsu, Naoki Takehara, Tetsuo |
author_facet | Makino, Yuki Shigekawa, Minoru Kegasawa, Tadashi Suda, Takahiro Yoshioka, Teppei Iwahashi, Kiyoshi Ikezawa, Kenji Sakamori, Ryotaro Yakushijin, Takayuki Kajihara, Jun Tomimaru, Yoshito Eguchi, Hidetoshi Imura, Yoshinori Outani, Hidetatsu Naka, Norifumi Honma, Keiichiro Morii, Eiichi Tatsumi, Tomohide Hiramatsu, Naoki Takehara, Tetsuo |
author_sort | Makino, Yuki |
collection | PubMed |
description | INTRODUCTION: Synovial sarcoma is a malignant soft tissue sarcoma which arises near joints. The most frequent metastasis sites of synovial sarcoma are the lungs, lymph nodes, and bone. Pancreatic metastasis is quite rare; only 3 cases have been reported worldwide to date. We herein present the 4th case of pancreatic metastasis from synovial sarcoma. METHODS AND RESULTS: A 32-year-old man underwent extended excision of synovial sarcoma in the left pelvis and femur in 2009. In 2013, follow-up contrast-enhanced computed tomography revealed a 35-mm heterogeneously enhanced mass in the pancreas body. Endoscopic ultrasound-guided fine needle aspiration of the mass revealed a diffuse proliferation of atypical spindle cells in a fascicular arrangement. Because the histology was quite similar to the resected specimen of synovial sarcoma in 2009, the mass was suspected to be a metastasis from synovial sarcoma. Laparoscopic distal pancreatectomy with adjuvant adriamycin/ifosfamide chemotherapy was subsequently performed. Synovial sarcoma-specific SS18-SSX1 (synovial sarcoma translocation, chromosome 18-synovial sarcoma X1) or SS18-SSX2 chimera mRNA was detected in the resected specimen, confirming the diagnosis of metastasis from synovial sarcoma. The patient did well for 30 months without recurrence. CONCLUSION: This case suggests that pancreatic metastasis from synovial sarcoma can be successfully treated by metastasectomy with adjuvant chemotherapy. |
format | Online Article Text |
id | pubmed-5265897 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-52658972017-02-06 A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy Makino, Yuki Shigekawa, Minoru Kegasawa, Tadashi Suda, Takahiro Yoshioka, Teppei Iwahashi, Kiyoshi Ikezawa, Kenji Sakamori, Ryotaro Yakushijin, Takayuki Kajihara, Jun Tomimaru, Yoshito Eguchi, Hidetoshi Imura, Yoshinori Outani, Hidetatsu Naka, Norifumi Honma, Keiichiro Morii, Eiichi Tatsumi, Tomohide Hiramatsu, Naoki Takehara, Tetsuo Medicine (Baltimore) 4500 INTRODUCTION: Synovial sarcoma is a malignant soft tissue sarcoma which arises near joints. The most frequent metastasis sites of synovial sarcoma are the lungs, lymph nodes, and bone. Pancreatic metastasis is quite rare; only 3 cases have been reported worldwide to date. We herein present the 4th case of pancreatic metastasis from synovial sarcoma. METHODS AND RESULTS: A 32-year-old man underwent extended excision of synovial sarcoma in the left pelvis and femur in 2009. In 2013, follow-up contrast-enhanced computed tomography revealed a 35-mm heterogeneously enhanced mass in the pancreas body. Endoscopic ultrasound-guided fine needle aspiration of the mass revealed a diffuse proliferation of atypical spindle cells in a fascicular arrangement. Because the histology was quite similar to the resected specimen of synovial sarcoma in 2009, the mass was suspected to be a metastasis from synovial sarcoma. Laparoscopic distal pancreatectomy with adjuvant adriamycin/ifosfamide chemotherapy was subsequently performed. Synovial sarcoma-specific SS18-SSX1 (synovial sarcoma translocation, chromosome 18-synovial sarcoma X1) or SS18-SSX2 chimera mRNA was detected in the resected specimen, confirming the diagnosis of metastasis from synovial sarcoma. The patient did well for 30 months without recurrence. CONCLUSION: This case suggests that pancreatic metastasis from synovial sarcoma can be successfully treated by metastasectomy with adjuvant chemotherapy. Wolters Kluwer Health 2016-09-30 /pmc/articles/PMC5265897/ /pubmed/27684804 http://dx.doi.org/10.1097/MD.0000000000004789 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 4500 Makino, Yuki Shigekawa, Minoru Kegasawa, Tadashi Suda, Takahiro Yoshioka, Teppei Iwahashi, Kiyoshi Ikezawa, Kenji Sakamori, Ryotaro Yakushijin, Takayuki Kajihara, Jun Tomimaru, Yoshito Eguchi, Hidetoshi Imura, Yoshinori Outani, Hidetatsu Naka, Norifumi Honma, Keiichiro Morii, Eiichi Tatsumi, Tomohide Hiramatsu, Naoki Takehara, Tetsuo A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy |
title | A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy |
title_full | A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy |
title_fullStr | A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy |
title_full_unstemmed | A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy |
title_short | A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy |
title_sort | case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265897/ https://www.ncbi.nlm.nih.gov/pubmed/27684804 http://dx.doi.org/10.1097/MD.0000000000004789 |
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