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Atorvastatin inhibits insulin synthesis by inhibiting the Ras/Raf/ERK/CREB pathway in INS-1 cells

BACKROUND: Type 2 diabetes has become a global epidemic disease. Atorvastatin has become a cornerstone in the prevention and treatment of atherosclerosis. However, increasing evidence showed that statins can dose-dependently increase the risk of diabetes mellitus. The mechanism is not clear. OBJECTI...

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Detalles Bibliográficos
Autores principales: Sun, Hongxi, Li, Yu, Sun, Bei, Hou, Ningning, Yang, Juhong, Zheng, Miaoyan, Xu, Jie, Wang, Jingyu, Zhang, Yi, Zeng, Xianwei, Shan, Chunyan, Chang, Bai, Chen, Liming, Chang, Baocheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265918/
https://www.ncbi.nlm.nih.gov/pubmed/27684825
http://dx.doi.org/10.1097/MD.0000000000004906