Cargando…

Atorvastatin inhibits insulin synthesis by inhibiting the Ras/Raf/ERK/CREB pathway in INS-1 cells

BACKROUND: Type 2 diabetes has become a global epidemic disease. Atorvastatin has become a cornerstone in the prevention and treatment of atherosclerosis. However, increasing evidence showed that statins can dose-dependently increase the risk of diabetes mellitus. The mechanism is not clear. OBJECTI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Hongxi, Li, Yu, Sun, Bei, Hou, Ningning, Yang, Juhong, Zheng, Miaoyan, Xu, Jie, Wang, Jingyu, Zhang, Yi, Zeng, Xianwei, Shan, Chunyan, Chang, Bai, Chen, Liming, Chang, Baocheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer Health 2016
Materias:	4300
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265918/ https://www.ncbi.nlm.nih.gov/pubmed/27684825 http://dx.doi.org/10.1097/MD.0000000000004906

Ejemplares similares

Plasma Aldosterone Concentration Is Positively Associated With Pulse Pressure in Patients With Primary Hypertension
por: Yao, Xiaoguang, et al.
Publicado: (2015)

A meta-analysis of the influence of body mass index on the clinicopathologic progression of papillary thyroid carcinoma
por: Cui, Ningning, et al.
Publicado: (2021)

Hyperinsulinemia Can Cause Kidney Disease in the IGT Stage of OLETF Rats via the INS/IRS-1/PI3-K/Akt Signaling Pathway
por: Zhang, Yi, et al.
Publicado: (2019)

The anteroposterior diameter of nodules in the risk assessment of papillary thyroid microcarcinoma
por: Huang, Kun, et al.
Publicado: (2018)

Liuwei Dihuang pill treats diabetic nephropathy in rats by inhibiting of TGF-β/SMADS, MAPK, and NF-kB and upregulating expression of cytoglobin in renal tissues
por: Xu, Zhong Ju, et al.
Publicado: (2017)

Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
por: Ilter, Metehan, et al.
Publicado: (2022)

Reporting quality of polycystic ovary syndrome practice guidelines based on the RIGHT checklist
por: Li, Hongzhu, et al.
Publicado: (2020)

Bisphosphonates as a therapeutic choice for multifocal epithelioid hemangioma of bone: A case report
por: Tang, Lizhi, et al.
Publicado: (2019)

Incidence and risk factors for occult lesions in low-risk papillary thyroid microcarcinoma patients with tumor characteristics appropriate for thermal ablation: A retrospective study
por: Jin, Langping, et al.
Publicado: (2023)

A randomized controlled clinical study on Zuo's acupuncture treatment for prediabetes
por: Zeng, Xuanli, et al.
Publicado: (2022)

Impact of Diabetes on Stroke Risk and Outcomes: Two Nationwide Retrospective Cohort Studies
por: Liao, Chien-Chang, et al.
Publicado: (2015)

T cell leukemia control via Ras-Raf pathway inhibition with peptides
por: Marin, G, et al.
Publicado: (2017)

Impact of demographic characteristics and antihyperglycemic and cardiovascular drugs on the cardiorenal benefits of SGLT2 inhibitors in patients with type 2 diabetes mellitus: A protocol for systematic review and meta-analysis
por: Chang, Rong, et al.
Publicado: (2021)

Efficacy of combined angiotensin II receptor blocker with tripterygium glycosides on diabetic nephropathy: A protocol for meta-analysis
por: Ma, Chang-e, et al.
Publicado: (2021)

Systematic review and meta-analysis of stress management intervention studies in patients with metabolic syndrome combined with psychological symptoms
por: Lihua, Ma, et al.
Publicado: (2023)

The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A protocol for systematic review and meta-analysis
por: Li, Jie, et al.
Publicado: (2022)

Lack of association between single nucleotide polymorphisms in TCF7L2 and T2DM in the Chinese Yao population: A case-control study
por: Sun, Shi-Yu, et al.
Publicado: (2021)

The roles of first phase, second phase insulin secretion, insulin resistance, and glucose effectiveness of having prediabetes in nonobese old Chinese women
por: Lu, Chieh-Hua, et al.
Publicado: (2020)

By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis
por: Gao, Jiujiao, et al.
Publicado: (2015)

Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway
por: Wu, Dongdong, et al.
Publicado: (2019)

Ultrasound guided microwave ablation of thyroid nodular goiter and cystadenoma: A single center, large cohort study
por: Honglei, Gao, et al.
Publicado: (2021)

Effects of different weight loss dietary interventions on body mass index and glucose and lipid metabolism in obese patients
por: Ma, Yahui, et al.
Publicado: (2023)

Assessment of Blood Glucose Regulation and Safety of Resistant Starch Formula-Based Diet in Healthy Normal and Subjects With Type 2 Diabetes
por: Lin, Chia-Hung, et al.
Publicado: (2015)

Promoting Diabetic Wound Therapy Using Biodegradable rhPDGF-Loaded Nanofibrous Membranes: CONSORT-Compliant Article
por: Lee, Cheng-Hung, et al.
Publicado: (2015)

Comparison of jet injector and insulin pen in controlling plasma glucose and insulin concentrations in type 2 diabetic patients
por: Guo, Lixin, et al.
Publicado: (2017)

The status of stigma in patients with type 2 diabetes mellitus and its association with medication adherence and quality of life in China: A cross-sectional study
por: Li, Xiaoyan, et al.
Publicado: (2023)

A rare case report of very low thyroglobulin and a negative whole-body scan in a patient with a solid variant of papillary thyroid carcinoma with distant metastases
por: Li, Wei, et al.
Publicado: (2017)

Cross-sectional investigation of serum creatine kinase concentration in Graves disease patients treated with oral antithyroid drugs
por: Cheng, Ying, et al.
Publicado: (2020)

Effectiveness of empowerment-based intervention on HbA1c and self-efficacy among cases with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials
por: Chen, Yanyan, et al.
Publicado: (2021)

Endocrine characteristics and risk factors of type 2 diabetes complicated with gastrointestinal autonomic neuropathy: A single-center retrospective study
por: Guan, Wei, et al.
Publicado: (2023)

Nailfold capillary abnormalities are associated with type 2 diabetes progression and correlated with peripheral neuropathy
por: Hsu, Po-Chi, et al.
Publicado: (2016)

Low ambient temperatures correlate with increased risk of hypoglycemia in patients with type 2 diabetes: An ecological study in Taiwan
por: Lai, Shih-Wei, et al.
Publicado: (2020)

Traditional Chinese medicine body constitution predicts new-onset diabetic albuminuria in patients with type 2 diabetes: Taichung diabetic body constitution prospective cohort study
por: Lee, Cheng-Hung, et al.
Publicado: (2022)

Spontaneous and transient predinner hyperglycemia in some patients with diabetes: Dusk phenomenon
por: Li, Wei, et al.
Publicado: (2016)

Association factor analysis between osteoporosis with cerebral artery disease: The STROBE study
por: Jin, Eun-Sun, et al.
Publicado: (2017)

Effect of body shape on the development of cardiovascular disease in individuals with metabolically healthy obesity
por: Oh, Chang-Myung, et al.
Publicado: (2020)

The Diffuse Sclerosing Variant of Papillary Thyroid Cancer Presenting as Innumerable Diffuse Microcalcifications in Underlying Adolescent Hashimoto's Thyroiditis: A Case Report
por: Jeong, Sun Hye, et al.
Publicado: (2016)

Horner syndrome as a postoperative complication after minimally invasive video-assisted thyroidectomy: A case report
por: Hu, Xiaolei, et al.
Publicado: (2017)

Eight rare urinary disorders in a patient with Kallmann syndrome: A case report
por: Tian, Huining, et al.
Publicado: (2020)

Case report of 49,XXXXY syndrome with cleft palate, diabetes, hypothyroidism, and cataracts
por: Wei, Limin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_p7j9t4uh6q5thp2ns2jcpup3ct