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Length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester

Antenatal diagnosis of congenital heart disease (CHD) is still low even though screening was first introduced over 25 years ago. The purpose of our study was to determine the efficacy of a second-trimester prenatal ultrasonographic method of screening for CHD. From September 2012 to September 2013,...

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Autores principales: Chiu, Wei-Hsiu, Lee, Shy-Ming, Tung, Tao-Hsin, Tang, Xiao-Mei, Liu, Ren-Shyan, Chen, Ran-Chou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265924/
https://www.ncbi.nlm.nih.gov/pubmed/27684831
http://dx.doi.org/10.1097/MD.0000000000004928
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author Chiu, Wei-Hsiu
Lee, Shy-Ming
Tung, Tao-Hsin
Tang, Xiao-Mei
Liu, Ren-Shyan
Chen, Ran-Chou
author_facet Chiu, Wei-Hsiu
Lee, Shy-Ming
Tung, Tao-Hsin
Tang, Xiao-Mei
Liu, Ren-Shyan
Chen, Ran-Chou
author_sort Chiu, Wei-Hsiu
collection PubMed
description Antenatal diagnosis of congenital heart disease (CHD) is still low even though screening was first introduced over 25 years ago. The purpose of our study was to determine the efficacy of a second-trimester prenatal ultrasonographic method of screening for CHD. From September 2012 to September 2013, the length and width of the fetal ductus venosus were measured sonographically in 1006 singleton fetuses, and the ratio of length to width was calculated. The accuracy of each fetal measurement and Doppler ultrasonography were determined. The standard fetal echocardiographic evaluations including 2-dimensional gray-scale imaging, color, and Doppler color flow mapping were performed. The transducer was aligned to the long axis of the fetal trunk to view the ductus venosus in its full length, including the inlet (isthmus) and outlet portions of the vessel. The diameters of the vessel inner wall and mid-point of the ductus venosus were measured using calipers. All scans and fetal measurements were conducted by a registered sonographer with more than 20 years of perinatal ultrasound screening experience. Of the 1006 singleton fetuses between 19(+0) and 28(+6) weeks’ gestation, 36 had CHD. The ductus venosus length/width ratio (DVR) for the first CHD screening was extremely sensitive at 88.90%, with a specificity of 99.10% for the cardiac abnormalities included in this study. Chromosomal anomalies accompanied CHD in 0.4% (4/1006) of all cases and 11.11% (4/36) of the CHD cases. The DVR differed significantly between fetuses with CHD and normal fetuses during the second trimester. Careful assessment of the ratio should be a part of the sonographic examination of every fetus. In the case of a small DVR, advanced echocardiography and karyotype analysis should be performed. The ratio is a helpful tool for screening CHD abnormalities prenatally in the Chinese population.
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spelling pubmed-52659242017-02-06 Length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester Chiu, Wei-Hsiu Lee, Shy-Ming Tung, Tao-Hsin Tang, Xiao-Mei Liu, Ren-Shyan Chen, Ran-Chou Medicine (Baltimore) 5600 Antenatal diagnosis of congenital heart disease (CHD) is still low even though screening was first introduced over 25 years ago. The purpose of our study was to determine the efficacy of a second-trimester prenatal ultrasonographic method of screening for CHD. From September 2012 to September 2013, the length and width of the fetal ductus venosus were measured sonographically in 1006 singleton fetuses, and the ratio of length to width was calculated. The accuracy of each fetal measurement and Doppler ultrasonography were determined. The standard fetal echocardiographic evaluations including 2-dimensional gray-scale imaging, color, and Doppler color flow mapping were performed. The transducer was aligned to the long axis of the fetal trunk to view the ductus venosus in its full length, including the inlet (isthmus) and outlet portions of the vessel. The diameters of the vessel inner wall and mid-point of the ductus venosus were measured using calipers. All scans and fetal measurements were conducted by a registered sonographer with more than 20 years of perinatal ultrasound screening experience. Of the 1006 singleton fetuses between 19(+0) and 28(+6) weeks’ gestation, 36 had CHD. The ductus venosus length/width ratio (DVR) for the first CHD screening was extremely sensitive at 88.90%, with a specificity of 99.10% for the cardiac abnormalities included in this study. Chromosomal anomalies accompanied CHD in 0.4% (4/1006) of all cases and 11.11% (4/36) of the CHD cases. The DVR differed significantly between fetuses with CHD and normal fetuses during the second trimester. Careful assessment of the ratio should be a part of the sonographic examination of every fetus. In the case of a small DVR, advanced echocardiography and karyotype analysis should be performed. The ratio is a helpful tool for screening CHD abnormalities prenatally in the Chinese population. Wolters Kluwer Health 2016-09-30 /pmc/articles/PMC5265924/ /pubmed/27684831 http://dx.doi.org/10.1097/MD.0000000000004928 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5600
Chiu, Wei-Hsiu
Lee, Shy-Ming
Tung, Tao-Hsin
Tang, Xiao-Mei
Liu, Ren-Shyan
Chen, Ran-Chou
Length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester
title Length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester
title_full Length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester
title_fullStr Length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester
title_full_unstemmed Length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester
title_short Length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester
title_sort length to width ratio of the ductus venosus in simple screening for fetal congenital heart diseases in the second trimester
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5265924/
https://www.ncbi.nlm.nih.gov/pubmed/27684831
http://dx.doi.org/10.1097/MD.0000000000004928
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