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Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer

The aim of this study is to compare the effects of propofol and sevoflurane anesthesia on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer. Sixty patients with cervical cancer scheduled for elective laparoscopic radical hysterectomy under gen...

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Autores principales: Liu, Songtao, Gu, Xinyu, Zhu, Lijiao, Wu, Guannan, Zhou, Hai, Song, Yan, Wu, Congyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266001/
https://www.ncbi.nlm.nih.gov/pubmed/27930529
http://dx.doi.org/10.1097/MD.0000000000005479
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author Liu, Songtao
Gu, Xinyu
Zhu, Lijiao
Wu, Guannan
Zhou, Hai
Song, Yan
Wu, Congyou
author_facet Liu, Songtao
Gu, Xinyu
Zhu, Lijiao
Wu, Guannan
Zhou, Hai
Song, Yan
Wu, Congyou
author_sort Liu, Songtao
collection PubMed
description The aim of this study is to compare the effects of propofol and sevoflurane anesthesia on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer. Sixty patients with cervical cancer scheduled for elective laparoscopic radical hysterectomy under general anesthesia were randomized into 2 groups. TIVA group received propofol induction and maintenance and SEVO group received sevoflurane induction and maintenance. Blood samples were collected at 30 min before induction (T(0)); the end of the operation (T(1)); and 24 h (T(2)), 48 h (T(3)), and 72 h (T(4)) after operation. The T lymphocyte subsets (including CD3+ cells, CD4+ cells, and CD8+ cells) and CD4+/CD8+ ratio, natural killer (NK) cells, and B lymphocytes were analyzed by flow cytometry. After surgery, all immunological indicators except CD8+ cells were significantly decreased in both groups compared to basal levels in T(0), and the counts of CD3+ cells, CD4+ cells, NK cells, and the CD4+/CD8+ ratios were significantly lower in the SEVO groups than that in the TIVA group. However, the numbers of B cells were comparable at all the time points between 2 groups. Laparoscopic radical hysterectomy for cervical cancer is associated with postoperative lymphopenia. In terms of protecting circulating lymphocytes, propofol is superior to sevoflurane.
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spelling pubmed-52660012017-02-06 Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer Liu, Songtao Gu, Xinyu Zhu, Lijiao Wu, Guannan Zhou, Hai Song, Yan Wu, Congyou Medicine (Baltimore) 3300 The aim of this study is to compare the effects of propofol and sevoflurane anesthesia on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer. Sixty patients with cervical cancer scheduled for elective laparoscopic radical hysterectomy under general anesthesia were randomized into 2 groups. TIVA group received propofol induction and maintenance and SEVO group received sevoflurane induction and maintenance. Blood samples were collected at 30 min before induction (T(0)); the end of the operation (T(1)); and 24 h (T(2)), 48 h (T(3)), and 72 h (T(4)) after operation. The T lymphocyte subsets (including CD3+ cells, CD4+ cells, and CD8+ cells) and CD4+/CD8+ ratio, natural killer (NK) cells, and B lymphocytes were analyzed by flow cytometry. After surgery, all immunological indicators except CD8+ cells were significantly decreased in both groups compared to basal levels in T(0), and the counts of CD3+ cells, CD4+ cells, NK cells, and the CD4+/CD8+ ratios were significantly lower in the SEVO groups than that in the TIVA group. However, the numbers of B cells were comparable at all the time points between 2 groups. Laparoscopic radical hysterectomy for cervical cancer is associated with postoperative lymphopenia. In terms of protecting circulating lymphocytes, propofol is superior to sevoflurane. Wolters Kluwer Health 2016-12-09 /pmc/articles/PMC5266001/ /pubmed/27930529 http://dx.doi.org/10.1097/MD.0000000000005479 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 3300
Liu, Songtao
Gu, Xinyu
Zhu, Lijiao
Wu, Guannan
Zhou, Hai
Song, Yan
Wu, Congyou
Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer
title Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer
title_full Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer
title_fullStr Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer
title_full_unstemmed Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer
title_short Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer
title_sort effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer
topic 3300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266001/
https://www.ncbi.nlm.nih.gov/pubmed/27930529
http://dx.doi.org/10.1097/MD.0000000000005479
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