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Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis

BACKGROUND: The differential subcellular localizations of β-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of β-catenin and the prognosis of CRC patients remains u...

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Autores principales: Zhang, Shizhen, Wang, Zhen, Shan, Jinlan, Yu, Xiuyan, Li, Ling, Lei, Rui, Lin, Daozhe, Guan, Siqi, Wang, Xiaochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266024/
https://www.ncbi.nlm.nih.gov/pubmed/27930552
http://dx.doi.org/10.1097/MD.0000000000005546
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author Zhang, Shizhen
Wang, Zhen
Shan, Jinlan
Yu, Xiuyan
Li, Ling
Lei, Rui
Lin, Daozhe
Guan, Siqi
Wang, Xiaochen
author_facet Zhang, Shizhen
Wang, Zhen
Shan, Jinlan
Yu, Xiuyan
Li, Ling
Lei, Rui
Lin, Daozhe
Guan, Siqi
Wang, Xiaochen
author_sort Zhang, Shizhen
collection PubMed
description BACKGROUND: The differential subcellular localizations of β-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of β-catenin and the prognosis of CRC patients remains undetermined. METHODS: Systematic strategies were applied to search for eligible published studies in the PubMed, Embase, and Web of Science databases. The correlation between each subcellular localizations of β-catenin expression and patients’ clinicopathological features or prognosis was analyzed. RESULTS: Finally, this meta-analysis, including 6238 cases from 34 studies, revealed that β-catenin overexpression in the nucleus (HR: 1.50[95% CI: 1.08–2.10]) or reduced expression of β-catenin in the membrane (HR: 1.33[95% CI: 1.15–1.54]) significantly correlated with lower 5-year overall survival (OS). Conversely, overexpression of β-catenin in the cytoplasm (HR: 1.00[95% CI: 0.85–1.18]) did not show significant association with 5-year OS. CONCLUSION: This study suggested that β-catenin overexpression in the nucleus or reduced expression in the membrane, but not its overexpression in cytoplasm, could serve as a valuable prognostic predictor for CRC. However, additional large and well-designed prospective studies are required to verify our results.
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spelling pubmed-52660242017-02-06 Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis Zhang, Shizhen Wang, Zhen Shan, Jinlan Yu, Xiuyan Li, Ling Lei, Rui Lin, Daozhe Guan, Siqi Wang, Xiaochen Medicine (Baltimore) 5700 BACKGROUND: The differential subcellular localizations of β-catenin (including membrane, cytoplasm, and nucleus) play different roles in the progression of colorectal cancer (CRC). However, the correlation between each subcellular localization of β-catenin and the prognosis of CRC patients remains undetermined. METHODS: Systematic strategies were applied to search for eligible published studies in the PubMed, Embase, and Web of Science databases. The correlation between each subcellular localizations of β-catenin expression and patients’ clinicopathological features or prognosis was analyzed. RESULTS: Finally, this meta-analysis, including 6238 cases from 34 studies, revealed that β-catenin overexpression in the nucleus (HR: 1.50[95% CI: 1.08–2.10]) or reduced expression of β-catenin in the membrane (HR: 1.33[95% CI: 1.15–1.54]) significantly correlated with lower 5-year overall survival (OS). Conversely, overexpression of β-catenin in the cytoplasm (HR: 1.00[95% CI: 0.85–1.18]) did not show significant association with 5-year OS. CONCLUSION: This study suggested that β-catenin overexpression in the nucleus or reduced expression in the membrane, but not its overexpression in cytoplasm, could serve as a valuable prognostic predictor for CRC. However, additional large and well-designed prospective studies are required to verify our results. Wolters Kluwer Health 2016-12-09 /pmc/articles/PMC5266024/ /pubmed/27930552 http://dx.doi.org/10.1097/MD.0000000000005546 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5700
Zhang, Shizhen
Wang, Zhen
Shan, Jinlan
Yu, Xiuyan
Li, Ling
Lei, Rui
Lin, Daozhe
Guan, Siqi
Wang, Xiaochen
Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis
title Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis
title_full Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis
title_fullStr Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis
title_full_unstemmed Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis
title_short Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: A meta-analysis
title_sort nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma: a meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266024/
https://www.ncbi.nlm.nih.gov/pubmed/27930552
http://dx.doi.org/10.1097/MD.0000000000005546
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