Successfully treated congenital cystic adenomatoid malformation by open fetal surgery: A care-compliant case report of a 5-year follow-up and review of the literature

BACKGROUND: Congenital cystic adenomatoid malformation (CCAM) is a rare hamartomatous cystic lesion. Open fetal surgery currently provides a potential therapeutic option for management of a fetus with CCAM diagnosis. CASE SUMMARY: A 22-year-old G2P0 woman presented at [Image: see text] weeks’ gestation for evaluation of a fetus with a left lung lesion and diagnosed as CCAM at [Image: see text] weeks’ gestation. Open fetal surgery was performed to resection the lesion at [Image: see text] weeks’ gestation under deep maternal general anesthesia. The mother presented at [Image: see text] weeks after open fetal surgery with preterm premature rupture of membranes (PPROM) and underwent cesarean delivery at [Image: see text] weeks’ gestation. A vigorous woman infant of 1955 g, with good Apgar score, was delivered. At 1 month, 4 years, and present, 5 years after birth, she has continued to do well without any obvious deficit and both respiration and circulation were well maintained. CONCLUSION: We present one case of CCAM which was cured by open fetal surgery and continued to do well at follow-up of 5 years. The success of treatment provided preliminary experience for further carrying out such interventions in China.