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Targeting of Wnt/β-Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy

BACKGROUND: Aberrant activation of Wnt/β-catenin has been shown to promote ovarian cancer proliferation and chemoresistance. Pyrvinium, an FDA-approved anthelmintic drug, has been identified as a potent Wnt inhibitor. Pyrvinium may sensitize ovarian cancer cells to chemotherapy. MATERIAL/METHODS: Th...

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Detalles Bibliográficos
Autores principales:	Zhang, Chongyuan, Zhang, Zhenge, Zhang, Shuirong, Wang, Wenrong, Hu, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2017
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266205/ https://www.ncbi.nlm.nih.gov/pubmed/28090074 http://dx.doi.org/10.12659/MSM.901667

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