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Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes
Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is one mechanism for buffering against genetic pe...
Autores principales: | Ishikawa, Koji, Makanae, Koji, Iwasaki, Shintaro, Ingolia, Nicholas T., Moriya, Hisao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266272/ https://www.ncbi.nlm.nih.gov/pubmed/28121980 http://dx.doi.org/10.1371/journal.pgen.1006554 |
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